Open AccessJournal Article
Dopamine can be released by two mechanisms differentially affected by the dopamine transport inhibitor nomifensine.
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This article is published in Journal of Pharmacology and Experimental Therapeutics.The article was published on 1979-02-01 and is currently open access. It has received 396 citations till now. The article focuses on the topics: Dopamine transport & Dopaminergic.read more
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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
TL;DR: In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission.
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Mechanisms of neurotransmitter release by amphetamines: a review.
TL;DR: Current issues on the two apparent primary mechanisms--the redistribution of catecholamines from synaptic vesicles to the cytosol, and induction of reverse transport of transmitter through plasma membrane uptake carriers are reviewed.
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Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review
TL;DR: The results suggest that the changes in BP following changes in DA concentration might not be fully accounted by a simple occupancy model, and the data are reviewed supporting that agonist-mediated receptor internalization might play an important role in characterizing receptor-ligand interactions.
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New insights into the mechanism of action of amphetamines.
TL;DR: New insights are obtained into the molecular mechanisms whereby amphetamine, and the closely related compounds methamphetamine and methylenedioxymethamphetamine, cause monoamine, and particularly dopamine, release, which have potential implications for both amphetamine- and methamphetamine-induced neurotoxicity, as well as dopaminergic neurodegenerative diseases.
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Mechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter
TL;DR: Findings suggest that in the absence of pharmacological manipulation, such as the use of amphetamine, endogenous cytoplasmic DA normally does not reach sufficient concentrations to reverse the DAT.