Journal ArticleDOI
Dose-rate and oxygen effects in models of lipid membranes: linoleic acid.
TLDR
Radical scavenging experiments indicate that hydroxyl radical attack initiates the oxidative damage, and Dimethyl sulphoxide is exceptional in that it does not protect, but sensitizes, linoleic acid to radiation induced peroxidation.Abstract:
Cellular membranes have been suggested as possible loci for the development of the oxygen effect in radiobiology. Unsaturated lipids from membranes are subject to very efficient radiation-induced peroxidation, and the deleterious effects generally associated with lipid autoxidation could be initiated by ionizing radiation. Oxidative damage in lipids is characterized not only by high yields but also by a profound dose-rate effect. At dose-rates of X-irradiation below 100 rad/min, a very sharp rise occurs in oxidative damage. This damage has been quantified spectrophotometrically in terms of diene conjugation (O.D. 234 mm) and chromatographically in terms of specific 9- and 13-hydroperoxide formation in linoleic acid micelles. Radical scavenging experiments indicate that hydroxyl radical attack initiates the oxidative damage. Dimethyl sulphoxide is exceptional in that it does not protect, but sensitizes, linoleic acid to radiation induced peroxidation. The yields of hydroperoxides are substantial (G=10--40) and can be related to biological changes known to be effected by autoxidizing lipids.read more
Citations
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Journal ArticleDOI
Lipid peroxidation and mechanisms of toxicity.
Alan A. Horton,Steven Fairhurst +1 more
TL;DR: The possibility exists that certain foreign compounds may interfere with or even overwhelm these defenses, and herein could lie a general mechanism of toxicity.
Journal ArticleDOI
Liposomes as membrane model for study of lipid peroxidation.
S.N. Chatterjee,Sanjiv Agarwal +1 more
TL;DR: The properties, production and characterization of liposomes with special reference to their use as membrane model for the study of lipid peroxidation are described and special advantages these liposome provide in elucidating the mechanism of lipidperoxidation by different physical and chemical agents are brought out.
Journal ArticleDOI
The effect of ionizing radiation on lipid membranes
TL;DR: Two main objectives are envisaged: Radiation induced modification of membrane transport and the «inverse dose rate effect».
Journal ArticleDOI
Influence of Ginger Rhizome (Zingiber officinale Rosc) on Survival, Glutathione and Lipid Peroxidation in Mice after Whole-Body Exposure to Gamma Radiation
TL;DR: The ZOE treatment protected mice from GI syndrome as well as bone marrow syndrome and had a dose-dependent antimicrobial activity against Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli and Candida albicans.
Journal ArticleDOI
Modulation of radiation-induced alteration in the antioxidant status of mice by naringin.
TL;DR: It is demonstrated that naringin protects mouse liver and intestine against the radiation-induced damage by elevating the antioxidant status and reducing the lipid peroxidation.
References
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Journal ArticleDOI
A compilation of specific bimolecular rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals with inorganic and organic compounds in aqueous solution
Michael Anbar,P. Neta +1 more
TL;DR: In this paper, a compilation of the available kinetic data on the reactivities of the primary species of radiolysis in aqueous solution is presented, covering hydrated electrons, hydrogen atoms and hydroxyl radicals.
Journal ArticleDOI
Chemical Radioprotection and Radiosensitization of Mammalian Cells Growing in Vitro
TL;DR: The radiosensitizing and radioprotective effects of various compounds have been characterized in Chinese hamster fibroblasts growing in vitro and in a model chemical system utilizing DNA as target, and Cysteamine is shown to protect primarily by adding to the pool of radical-reducing species, resulting in enhanced repair of free-radical damage in the targets.
Journal ArticleDOI
Peroxidative and radiation damage to isolated lysosomes.
TL;DR: The differential release and inactivation pattern of various enzymes suggest differences in molecular binding and organization of these enzymes in lysosomal particles.
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