Journal ArticleDOI
Double-blind, controlled, crossover study of cyclosporin in adults with severe refractory atopic dermatitis
J. M. Sowden,J. Berth-Jones,J.S. Ross,Richard Motley,Ronald Marks,Andrew Yule Finlay,Mir-saeed Salek,R.A.C. Graham-Brown,B.R. Allen,Richard D.R. Camp +9 more
TLDR
It is confirmed that cyclosporin is a safe and effective short-term treatment for severe, refractory atopic dermatitis.About:
This article is published in The Lancet.The article was published on 1991-07-20. It has received 371 citations till now. The article focuses on the topics: Atopic dermatitis & Topical steroid.read more
Citations
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Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
TL;DR: In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.
Journal ArticleDOI
Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis.
TL;DR: Investigation of the expression of interleukin 4, IL-5, and interferon-gamma messenger RNA in skin biopsies from acute and chronic skin lesions of patients with atopic dermatitis indicates that initiation of acute skin inflammation in AD is associated with a predominance of IL-4 expression whereas maintenance of chronic inflammation is predominantly associated with increasedIL-5 expression and eosinophil infiltration.
Journal ArticleDOI
Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report
Cezmi A. Akdis,M. Akdis,T. Bieber,Carsten Bindslev-Jensen,Mark Boguniewicz,Philippe Eigenmann,Qutayba Hamid,Alexander Kapp,Donald Y.M. Leung,J Lipozencic,Thomas A. Luger,Antonella Muraro,Natalija Novak,Thomas A.E. Platts-Mills,Lanny J. Rosenwasser,Annika Scheynius,F. E. R. Simons,Jonathan M. Spergel,K Turjanmaa,Ulrich Wahn,S Weidinger,Thomas Werfel,Torsten Zuberbier +22 more
TL;DR: The consensus report is endorsed by both academies and aims to serve as a guideline for clinical practice in Europe as well as in North America.
Journal ArticleDOI
Atopic dermatitis: New insights and opportunities for therapeutic intervention
TL;DR: This review will examine the cellular and molecular mechanisms that contribute to AD as well as the immunologic triggers involved in its pathogenesis to provide new opportunities for therapeutic intervention in this common skin condition.
Journal ArticleDOI
Induction of human IgE synthesis in B cells by mast cells and basophils
Jean François Gauchat,Sybille Henchoz,Gonzalo Mazzei,Jean Pierre Aubry,Thomas Brunner,Horst Blasey,Paul Life,Dominique Talabot,Leopoldo Flores-Romo,Jeffrey C. Thompson,Kenji Kishi,Joseph H. Butterfield,Clemens A. Dahinden,Jean Yves Bonnefoy +13 more
TL;DR: It is reported that, in the presence of IL-4, mast and basophilic cell lines can provide the cell contact signals that are required for IgE synthesis, suggesting that mast cells and Basophils may play a key role in allergy not only by producing inflammatory mediators, but also by directly regulating IgE production independently of T cells.
References
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Journal ArticleDOI
Efficacy of low-dose cyclosporine in severe atopic skin disease.
T. Van Joost,E. Stolz,F. Heule +2 more
TL;DR: The temporary effect of short-term cyclosporine treatment in two women with severe, drug-resistant, pruritic, activedisseminated, chronic prurigolike lesions and eczema is observed.
Journal ArticleDOI
Cyclosporin A in atopic dermatitis: therapeutic response is dissociated from effects on allergic reactions.
TL;DR: In this paper, cyclosporin A (CyA, Sandimmun; 5 mg/kg/day) was used to treat severe chronic atopic dermatitis for 7-16 weeks.
Journal ArticleDOI
Cyclosporin A in atopic dermatitis.
J.S. Ross,R.D.R. Camp +1 more
TL;DR: CyA appears to be useful in the treatment of severe, therapy‐resistant atopic dermatitis, but careful monitoring of side‐effects and dose adjustments are required.
Journal ArticleDOI
Cyclosporin: use outside transplantation.
A W Thomson,G H Neild +1 more
TL;DR: The value of a very high serum potassium concentration as a prognostic indicator in uncomplicated hypothermia is uncertain, but it may provide a guide to cases in which resuscitation cannot succeed for other reasons.