Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management
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TLDR
The most important aspects of patient management are a high index of suspicion and a careful history of drug exposure in an individual who presents with acute, often severe thrombocytopenia of unknown etiology.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2009-06-01 and is currently open access. It has received 280 citations till now.read more
Citations
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Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image-guided interventions.
Indravadan Patel,J. Davidson,Boris Nikolic,Gloria Salazar,Marc S. Schwartzberg,T. Gregory Walker,Wael A. Saad +6 more
TL;DR: From the Division of Vascular and Interventional Radiological, Jefferson Radiology, Hartford Hospital, 85 Seymour St, Ste 200, Hartford, CT 06106, Received November 18, 2008; accepted November 24, 2008.
Journal ArticleDOI
Idiosyncratic Adverse Drug Reactions: Current Concepts
Jack Uetrecht,Dean J. Naisbitt +1 more
TL;DR: It is not yet clear what fraction of IDRs have a strong HLA dependence, and most patients who have the HLA that confers a higher IDR risk with a specific drug will not have an IDR when treated with that drug.
Journal ArticleDOI
Drug-induced thrombocytopenia: pathogenesis, evaluation, and management
James N. George,Richard H. Aster +1 more
TL;DR: Recovery from DITP usually begins within 1 to 2 days of stopping the drug and is typically complete within a week, and it is important that the drug etiology be confirmed and the drug be avoided thereafter.
Journal ArticleDOI
Platelet bioreactor-on-a-chip
Jonathan N. Thon,Jonathan N. Thon,Jonathan N. Thon,Linas Mazutis,Linas Mazutis,Linas Mazutis,Stephen Wu,Joanna L. Sylman,Allen J. Ehrlicher,Allen J. Ehrlicher,Kellie R. Machlus,Kellie R. Machlus,Qiang Feng,Shi-Jiang Lu,Robert Lanza,Keith B. Neeves,Keith B. Neeves,David A. Weitz,Joseph E. Italiano +18 more
TL;DR: A microfluidic human platelet bioreactor is developed that recapitulates bone marrow stiffness, extracellular matrix composition, micro-channel size, hemodynamic vascular shear stress, and endothelial cell contacts, and supports high-resolution live-cell microscopy and quantification of platelet production.
Journal ArticleDOI
Thrombocytopenia in pregnancy.
TL;DR: In the review, the differential diagnosis of thrombocytopenia in pregnancy, and the pathogenesis of selected throm bocytopenic disorders are discussed.
References
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Serologically documented loracarbef (Lorabid)-induced immune thrombocytopenia.
TL;DR: It is reported here the first case of severe immune thrombocytopenia induced by a second‐generation cephalosporin antibiotic, Loracarbef, in a 56‐year old white female.
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Drug-induced thrombocytopenia: pathogenesis, evaluation, and management
James N. George,Richard H. Aster +1 more