Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management
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TLDR
The most important aspects of patient management are a high index of suspicion and a careful history of drug exposure in an individual who presents with acute, often severe thrombocytopenia of unknown etiology.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2009-06-01 and is currently open access. It has received 280 citations till now.read more
Citations
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Adequate evaluation of thrombocytopenias as a prerequisite to effective cardiac patient treatment
Journal ArticleDOI
Acute Isolated Thrombocytopenia Secondary to Meloxicam Use: A Case Report
TL;DR: A case of a 42-year-old Hispanic female who was recently started on meloxicam and presented with petechiae, ecchymosis, and a platelet count of 2 (normal 150-350 K/mm3).
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Purpura de henoch scholein relacionada con uso de rivaroxaban un evento adverso infrecuente y de mecanismos aun desconocidos, descripcion de un caso
Juan Sebastián Theran león,Luis Andrés Dulcey Sarmiento,Jhurgen Rolanlly Robles,Juan Ariel Torres Liñan,Melissa Julieth Aguas Cantillo +4 more
TL;DR: In this article , a paciente with trombosis venosa profunda profunda was diagnosticado de Purpura de Henoch Scholein debido al use of Rivaroxabán, luego de descartarse la mayoría de las posibilidades.
References
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Journal ArticleDOI
Heparin-induced thrombocytopenia.
Fabrizio Fabris,Guido Luzzatto,Piero Maria Stefani,Bruno Girolami,Giuseppe Cella,Antonio Girolami +5 more
TL;DR: The aim of this article is to review the most recent advances in the field and to give critical guidelines for the clinical diagnosis and treatment of HIT II, the most frequent and dangerous side-effect of heparin therapy.
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Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity : an explanation for the thrombotic complications of heparin-induced thrombocytopenia
Theodore E. Warkentin,Catherine P.M. Hayward,Lynn K. Boshkov,Aurelio Santos,Jo-Ann I. Sheppard,Arthur P. Bode,John G. Kelton +6 more
TL;DR: Observations indicate that the generation of procoagulant platelet-derived microparticles in vivo is a plausible explanation for the thrombotic complications observed in some patients with heparin-inducedThrombocytopenia.
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Drug-Induced Immune Thrombocytopenia
TL;DR: The current understanding of pathogenesis is summarized and a guide for diagnosis and management of thrombocytopenia is provided.
Journal ArticleDOI
Drug-Induced Thrombocytopenia: A Systematic Review of Published Case Reports
James N. George,Gary E. Raskob,Shehla Rizvi Shah,Mujahid A. Rizvi,Stephen A. Hamilton,Scott Osborne,Thomas Vondracek +6 more
TL;DR: This systematic review analyzed all published reports of drug-induced thrombocytopenia by using explicit, a priori criteria for establishing levels of evidence of a causal relation to help clinicians better understand the likelihood that a drug will cause throm bocy topenia.
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Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.
TL;DR: Fab fragments of certain antibodies against LIBS on integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) block platelet aggregation, and changes in the conformation of this integrin modulate both the specificity and affinity of ligand recognition.
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Drug-induced thrombocytopenia: pathogenesis, evaluation, and management
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