Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management
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TLDR
The most important aspects of patient management are a high index of suspicion and a careful history of drug exposure in an individual who presents with acute, often severe thrombocytopenia of unknown etiology.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2009-06-01 and is currently open access. It has received 280 citations till now.read more
Citations
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Journal ArticleDOI
Delayed-type of hypersensitivity reaction due to piperacillin/tazobactam causing severe thrombocytopenia -
TL;DR: Delayed type of reaction with piperacillin/tazobactam warrants caution for clinicians to continue patients on this drug at home after discharge from the hospital, which is not an uncommon scenario in resource limited countries such as India.
Journal ArticleDOI
Tattoo Trouble: A Case of Drug-induced Thrombocytopenic Purpura.
TL;DR: A 34-year-old active duty marine male with no significant past medical history presented with a chief complaint of a rash on his lower extremities. The intern noted a petechial rash that was pathognomonic for thrombocytopenia as discussed by the authors.
Journal ArticleDOI
Drug-induced immune thrombocytopenia
TL;DR: Imuna trombocitopenija izazvana lekovima (ITIL) nastaje kao posledica destrukcije ili neadekvatne aktivacije tromBocita usled dejstva imunog sistema provociranog trenutnim ili pređasnjim prisustvom leka u organizmu.
Journal ArticleDOI
Drug-induced platelet disorders
TL;DR: Platelet dysfunction and destruction can be induced by several different drug-related mechanisms, and can result in mild-to-severe haemorrhage, and the mechanisms mediating these processes are outlined.
Book ChapterDOI
Neonatal Platelet Disorders
TL;DR: Large population-based studies have shown that platelet count increase with advancing gestational age, and platelet counts between 100 and 150 × 10 9 /L are more frequent among otherwise healthy extremely preterm infants than among full term neonates or older children.
References
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Journal ArticleDOI
Heparin-induced thrombocytopenia.
Fabrizio Fabris,Guido Luzzatto,Piero Maria Stefani,Bruno Girolami,Giuseppe Cella,Antonio Girolami +5 more
TL;DR: The aim of this article is to review the most recent advances in the field and to give critical guidelines for the clinical diagnosis and treatment of HIT II, the most frequent and dangerous side-effect of heparin therapy.
Journal ArticleDOI
Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity : an explanation for the thrombotic complications of heparin-induced thrombocytopenia
Theodore E. Warkentin,Catherine P.M. Hayward,Lynn K. Boshkov,Aurelio Santos,Jo-Ann I. Sheppard,Arthur P. Bode,John G. Kelton +6 more
TL;DR: Observations indicate that the generation of procoagulant platelet-derived microparticles in vivo is a plausible explanation for the thrombotic complications observed in some patients with heparin-inducedThrombocytopenia.
Journal ArticleDOI
Drug-Induced Immune Thrombocytopenia
TL;DR: The current understanding of pathogenesis is summarized and a guide for diagnosis and management of thrombocytopenia is provided.
Journal ArticleDOI
Drug-Induced Thrombocytopenia: A Systematic Review of Published Case Reports
James N. George,Gary E. Raskob,Shehla Rizvi Shah,Mujahid A. Rizvi,Stephen A. Hamilton,Scott Osborne,Thomas Vondracek +6 more
TL;DR: This systematic review analyzed all published reports of drug-induced thrombocytopenia by using explicit, a priori criteria for establishing levels of evidence of a causal relation to help clinicians better understand the likelihood that a drug will cause throm bocy topenia.
Journal ArticleDOI
Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.
TL;DR: Fab fragments of certain antibodies against LIBS on integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) block platelet aggregation, and changes in the conformation of this integrin modulate both the specificity and affinity of ligand recognition.
Related Papers (5)
Drug-induced thrombocytopenia: pathogenesis, evaluation, and management
James N. George,Richard H. Aster +1 more