Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management
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TLDR
The most important aspects of patient management are a high index of suspicion and a careful history of drug exposure in an individual who presents with acute, often severe thrombocytopenia of unknown etiology.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2009-06-01 and is currently open access. It has received 280 citations till now.read more
Citations
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Journal ArticleDOI
A Novel Association between Antiretroviral Therapy and Drug-Induced Immune Thrombocytopenia Purpura.
Journal ArticleDOI
[A Case of Thrombocytopenia Following Minocycline Administration].
Shiori Tomita,Ryohei Fujii,Y. Imai,Norito Nishiyama,Masayuki Tanaka,Kazuki Uchitani,Tatsuya Muranaka +6 more
TL;DR: In this paper , intravenous administration of MINO led to thrombocytopenia in an 80-year-old female patient who was receiving radiation therapy for tongue cancer and medication for pain control.
Dissertation
Immune thrombocytopaenia at a central hospital in Johannesburg
TL;DR: A Research Report submitted to the Faculty of Health Sciences, University of Witwatersrand, Johannesburg, in partial fulfilment of the degree of Master of Medicine in the branch of Internal Medicine.
Journal ArticleDOI
Chemotherapy-induced thrombocytopenia: literature review
TL;DR: In this article , a review on the epidemiology and treatment of cancer patients with CIT is presented, where the authors introduce some recent progress to understand the cellular and molecular mechanisms of chemotherapy inhibiting normal hematopoiesis and causing thrombocytopenia.
Journal ArticleDOI
Continuous use of enzalutamide in a patient who developed enzalutamide-induced thrombocytopenia
TL;DR: The case of a 69-year-old patient with metastatic castration-resistant prostate cancer who was started on enzalutamide at a dose of 160 mg/day is reported, suggesting that it is possible to again use enzalUTamide in patients who have developed enzyme-induced thrombocytopenia.
References
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Journal ArticleDOI
Heparin-induced thrombocytopenia.
Fabrizio Fabris,Guido Luzzatto,Piero Maria Stefani,Bruno Girolami,Giuseppe Cella,Antonio Girolami +5 more
TL;DR: The aim of this article is to review the most recent advances in the field and to give critical guidelines for the clinical diagnosis and treatment of HIT II, the most frequent and dangerous side-effect of heparin therapy.
Journal ArticleDOI
Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity : an explanation for the thrombotic complications of heparin-induced thrombocytopenia
Theodore E. Warkentin,Catherine P.M. Hayward,Lynn K. Boshkov,Aurelio Santos,Jo-Ann I. Sheppard,Arthur P. Bode,John G. Kelton +6 more
TL;DR: Observations indicate that the generation of procoagulant platelet-derived microparticles in vivo is a plausible explanation for the thrombotic complications observed in some patients with heparin-inducedThrombocytopenia.
Journal ArticleDOI
Drug-Induced Immune Thrombocytopenia
TL;DR: The current understanding of pathogenesis is summarized and a guide for diagnosis and management of thrombocytopenia is provided.
Journal ArticleDOI
Drug-Induced Thrombocytopenia: A Systematic Review of Published Case Reports
James N. George,Gary E. Raskob,Shehla Rizvi Shah,Mujahid A. Rizvi,Stephen A. Hamilton,Scott Osborne,Thomas Vondracek +6 more
TL;DR: This systematic review analyzed all published reports of drug-induced thrombocytopenia by using explicit, a priori criteria for establishing levels of evidence of a causal relation to help clinicians better understand the likelihood that a drug will cause throm bocy topenia.
Journal ArticleDOI
Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.
TL;DR: Fab fragments of certain antibodies against LIBS on integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) block platelet aggregation, and changes in the conformation of this integrin modulate both the specificity and affinity of ligand recognition.
Related Papers (5)
Drug-induced thrombocytopenia: pathogenesis, evaluation, and management
James N. George,Richard H. Aster +1 more