Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management
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TLDR
The most important aspects of patient management are a high index of suspicion and a careful history of drug exposure in an individual who presents with acute, often severe thrombocytopenia of unknown etiology.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2009-06-01 and is currently open access. It has received 280 citations till now.read more
Citations
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Journal ArticleDOI
Evaluation of spontaneous gingival bleeding and related drug withdrawal frequency in atrial fibrillation patients using oral anticoagulants: a case-controlled study
Mustafa Özcan,Hasan Koca +1 more
TL;DR: OAK tedavisi altindaki AF hastalarinda, onceden var olan periodontal hastalik nedeniyle onemli oranda SDK ve buna bagli hastanin OAK ilac kullanimini biraktigi tespit edildi risk indikatorudur.
Journal ArticleDOI
Immune Thrombocytopenia: A Rare Adverse Event of Vancomycin Therapy
TL;DR: In this paper , a case of a 56-year-old male with a diabetic foot with an infected exudating purulent ulcer was found to have vancomycin-induced immune thrombocytopenia.
Journal ArticleDOI
Piperacillin-Associated Immune Thrombocytopenia.
Leela Krishna Teja Boppana,Ahmed Elkhapery,Mindee Hite,Utsav Joshi,Nada Hafez,Michael N. Gurell +5 more
Journal ArticleDOI
Refractory immune thrombocytopenia (ITP) with suspected Evans syndrome requiring quadruple therapy
TL;DR: This case of recurrent severe form of ITP is reported, which is not only unique due to the aggressive treatment required, but also because patient also had investigation results suggestive of autoimmune hemolytic anemia raising suspicion of Evans Syndrome.
Journal ArticleDOI
Management of Select Thrombocytopenias.
TL;DR: The pathophysiology, patient presentation, diagnostic testing, and specific management strategies and challenges of these thrombocytopenias are reviewed.
References
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Journal ArticleDOI
Heparin-induced thrombocytopenia.
Fabrizio Fabris,Guido Luzzatto,Piero Maria Stefani,Bruno Girolami,Giuseppe Cella,Antonio Girolami +5 more
TL;DR: The aim of this article is to review the most recent advances in the field and to give critical guidelines for the clinical diagnosis and treatment of HIT II, the most frequent and dangerous side-effect of heparin therapy.
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Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity : an explanation for the thrombotic complications of heparin-induced thrombocytopenia
Theodore E. Warkentin,Catherine P.M. Hayward,Lynn K. Boshkov,Aurelio Santos,Jo-Ann I. Sheppard,Arthur P. Bode,John G. Kelton +6 more
TL;DR: Observations indicate that the generation of procoagulant platelet-derived microparticles in vivo is a plausible explanation for the thrombotic complications observed in some patients with heparin-inducedThrombocytopenia.
Journal ArticleDOI
Drug-Induced Immune Thrombocytopenia
TL;DR: The current understanding of pathogenesis is summarized and a guide for diagnosis and management of thrombocytopenia is provided.
Journal ArticleDOI
Drug-Induced Thrombocytopenia: A Systematic Review of Published Case Reports
James N. George,Gary E. Raskob,Shehla Rizvi Shah,Mujahid A. Rizvi,Stephen A. Hamilton,Scott Osborne,Thomas Vondracek +6 more
TL;DR: This systematic review analyzed all published reports of drug-induced thrombocytopenia by using explicit, a priori criteria for establishing levels of evidence of a causal relation to help clinicians better understand the likelihood that a drug will cause throm bocy topenia.
Journal ArticleDOI
Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.
TL;DR: Fab fragments of certain antibodies against LIBS on integrin alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) block platelet aggregation, and changes in the conformation of this integrin modulate both the specificity and affinity of ligand recognition.
Related Papers (5)
Drug-induced thrombocytopenia: pathogenesis, evaluation, and management
James N. George,Richard H. Aster +1 more