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Drugs producing diabetes through damage of the insulin secreting cells
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This article is published in Pharmacological Reviews.The article was published on 1970-12-01 and is currently open access. It has received 775 citations till now. The article focuses on the topics: Insulin & Diabetes mellitus.read more
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The mechanisms of alloxan- and streptozotocin-induced diabetes.
TL;DR: The targeting of mitochondrial DNA, thereby impairing the signalling function of beta cell mitochondrial metabolism, also explains how streptozotocin is able to inhibit glucose-induced insulin secretion, causing a state of insulin-dependent ‘alloxan diabetes’.
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Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
TL;DR: The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.
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The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors
László Virág,Csaba Szabó +1 more
TL;DR: The double-edged sword roles of PARP in DNA damage signaling and cell death are reviewed and the underlying mechanisms of the anti-inflammatory effects ofPARP inhibitors are summarized.
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Diet-induced type II diabetes in C57BL/6J mice.
TL;DR: The data suggest that the C57BL/6J mouse carries a genetic predisposition to develop non-insulin-dependent (type II) diabetes, and altered glycemic response to adrenergic stimulation may be a biologic marker for this genetic predispose to develop type II diabetes.
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Free radicals and diabetes
TL;DR: Not only are oxygen radicals involved in the cause of diabetes, they also appear to play a role in some of the complications seen in long-term treatment of diabetes.