Showing papers in "Pharmacological Research in 2005"

TL;DR: The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.

TL;DR: It is suggested that QE treatment has protective effect in diabetes by decreasing oxidative stress and preservation of pancreatic beta-cell integrity.

TL;DR: Structural features of PPARs, their gene transcription mechanisms and recent developments in the discovery of their biological functions are reviewed.

TL;DR: Review of literature on anticancer drugs of plant origin revealed identification of newer ayurvedic drugs that are not mentioned in the ancient texts, and details of experimental and clinical studies conducted on single and compound ayuvedic preparations for their anticancer efficacy strongly emphasize ayur Vedic therapy as a scientifically driven one and not simply unconventional.

TL;DR: Pharmacology and pharmacokinetics of memantine and other NMDA-receptor antagonists in comparison with currently approved drugs for dementia treatment have been discussed and the focus is on 'glutamate excitotoxicity' and glutamate receptors as drug target.

TL;DR: Modulation of PAR synthesis or degradation through the targeting of PARP-1 or PARG holds particular promise in the treatment of conditions such as cancer, stroke, and Parkinson's disease.

TL;DR: It is shown that a reduction in cortical BDNF messenger level correlates with the progression of the disease in a mouse model of HD, and the possibility that delivery of BDNF may represent an useful strategy for Huntington's disease treatment is discussed.

TL;DR: A brief overview of the recent literature on preclinical studies with the specific and potent inhibitors newly synthesized of Poly(ADP-ribose) polymerases is provided.

TL;DR: Recent findings concerning the neuronal effects of estrogens that may contribute to their neuroprotective actions are discussed, and both estrogen receptor-dependent and -independent mechanisms will be described.

TL;DR: The study suggests that GSP are effective in ameliorating the damage to pancreatic tissue in experimental diabetes mellitus due to their potent antioxidant properties as evidenced by the increase in pancreatic GSH and reduction of lipid peroxidation as well as total nitrate/nitrite levels.

TL;DR: It is suggested that propolis can control blood glucose and modulate the metabolism of glucose and blood lipid, leading to decreased outputs of lipid peroxidation and scavenge the free radicals in rats with diabetes mellitus.

TL;DR: It appears that on the cytoprotective aspect of PARP, acute, life-threatening diseases (myocardial infarction, cardiopulmonary bypass in high-risk patients, and other, severe forms of ischemia-reperfusion to other organs including stroke and thoracoabdominal aneurysm repair) may represent some of the prime development indications.

TL;DR: Meloxicam was the most advantageous for horses of four NSAIDs examined, and it is proposed that the selectivity of NSAIDs should be assessed at the 80% as well as 50% inhibition level.

TL;DR: The in vitro observed modulations and effects exerted by extracts derived from local food plants suggest that these plants may contribute to the observed better aging of rural Mediterranean populations.

TL;DR: Results suggest that lyophilised berries may be beneficial in the prevention of memory deficits, one of the symptoms related to AD, and corroborate previous findings showing that flavonoids present effects in several learning paradigms.

TL;DR: Four extracts exhibited a DPPH radical scavenging activity higher than that obtained from Ginkgo biloba, a reference plant with well documented antioxidant activity, suggesting that these plant extracts could be considered as potential sources of antioxidants.

TL;DR: The results suggest that SLN delivery system can enhance the anti-inflammatory activity of triptolide meanwhile has a protective effect against triPTolide-induced hepatotoxicity.

TL;DR: The urinary excretion rates of unmetabolised betalains were fast and appeared to be monoexponential suggesting a one-compartment model and it is assumed that either the bioavailability of the betalain is low or that renal clearance is a minor route of systemic elimination for these compounds.

TL;DR: Eight milligrams per kilograms of rosmarinic acid was enough to increase the locomotion and motivation of the animals, but not 1, 2 or 4 mg kg(-1), suggesting that in lower doses, this compound can produce anxiolytic-like effect without exerting locomotor alterations or DNA damage in brain tissue.

TL;DR: Recent experimental evidence implicating PARP as a pathophysiological modulator of acute and chronic inflammation is described.

TL;DR: This study demonstrates the effectiveness of JLW in combating inflammation in several experimental models and identifies the active constituents responsible for the anti-inflammatory property of jojoba liquid wax.

TL;DR: In this paper, the authors studied and confirmed the protective activity of icariin on H2O2-induced injury in human umbilical vein endothelial cell line: ECV-304.

TL;DR: The role of oxidative stress in the pathogenesis of CsA-induced kidney dysfunction is proved and Supplementation of GTE could be useful in reducing CsC nephrotoxicity in rats, however, clinical studies are warranted to investigate such an effect in human subjects.

TL;DR: The data proved that antioxidant property of α-asarone against noise-stress induced changes in the rat brain, and more clinical studies are required to investigate effectiveness of the α-aserone in noisy environment in human subjects.

TL;DR: The present findings are suggestive of ET-1's role in astroglial activation, particularly in response to elevated IOP in glaucoma, as seen in brain astrocytes subjected to neurotrauma.

TL;DR: The findings suggest that the inhibition of LPS-induced NO formation by amentoflavone is due to its inhibition of NF-kappaB by blocking I-kkappaBalpha degradation, which may be the mechanistic basis of the anti-inflammatory effects of ament oflavone.

TL;DR: An overview of the experimental evidence implicating PARP as a causative factor in the pathogenesis of diabetes and diabetic complications in vitro and in vivo is provided.

TL;DR: Results indicated that the degraded lambda-carrageenan could enhance antitumor activity of 5- Fu and improve immunocompetence damaged by 5-Fu.

TL;DR: A large body of evidence unambiguously demonstrates that activity of poly(ADP-ribose) polymerase-1 (PARP-1) significantly increases during brain ischemia, and that inhibition of this enzymatic activity affords substantial neuroprotection from ischemic brain injury.

TL;DR: In this article, 19 dehydroabietic acid diterpenes were assessed for gastroprotective activity in the HCl/EtOH-induced gastric lesions in mice as well as for cytotoxicity in human lung fibroblasts (MRC-5) and human epithelial gastric (AGS) cells.