Book ChapterDOI
Dynamic Changes in Dorsal Horn Neurons
W. D. WillisJr.
- pp 421-447
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TLDR
The responses of dorsal horn neurons to somatosensory stimulation can be altered under a variety of circumstances, including habituation following repeated stimulation of the excitatory receptive field and sensitization of primary afferent fibers.Abstract:
The responses of dorsal horn neurons to somatosensory stimulation can be altered under a variety of circumstances. For example, somatosensory responses of spinal cord dorsal horn neurons can be decreased by 1) habituation following repeated stimulation of the excitatory receptive field;46 2) stimulation of an inhibitory receptive field;30 3) activity in descending inhibitory pathways81 and 4) pathological changes leading to loss of primary afferent fibers.13 Conversely, somatosensory responses can be increased by such manipulations as 1) repeated stimulation of fine calibre primary afferent fibers (“wind-up”);47 2) spatial summation of excitatory inputs from different parts of the receptive field;49 3) volleys in excitatory pathways descending from the brain;80 and 4) sensitization of primary afferent fibers37 or of dorsal horn neurons as a consequence of damage to peripheral tissue or peripheral nerves.19,57read more
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Journal ArticleDOI
Noxious visceral inputs enhance cutaneous tactile response in rat thalamus
TL;DR: Twenty out of the 44 neurons had their response to tactile stimulation increased by preceding nociceptive colorectal distension (CRD), and this influence appear more potent than the opposite effect, tactile on CRD response.
Journal ArticleDOI
Intradermal injection of capsaicin induces acute substance P release from rat spinal cord dorsal horn.
TL;DR: This study has provided direct evidence of the effect of intradermal injection of capsaicin on SP release within the dorsal horn, with the major source being from the central terminals of primary afferents.
References
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Journal ArticleDOI
The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System
TL;DR: 'The following abbreviations have been used in the text'; I3-N-uxalyl-L-a,l3diaminu-prupiunic acid; ACPD, Trans-l-aminu-cydupentyl-I,3-dicarbuxylate; AMPA, a aminU-3-hydruxy-5-methyl-isoxazole-4-propionate; AP4, 2-
Journal ArticleDOI
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
Amy B. MacDermott,Amy B. MacDermott,Mark L. Mayer,Gary L. Westbrook,Stephen J. Smith,Jeffery L. Barker +5 more
TL;DR: It is directly demonstrated that excitatory amino acids acting at NMDA receptors on spinal cord neurones increase the intracellular Ca2+ activity, measured using the indicator dye arsenazo III, and that this is the result of Ca2- influx through NMDA receptor channels.
Journal ArticleDOI
The management of pain
TL;DR: In this article, a basic consideration of pain is presented, fundamental considerations basic aspects clinical aspects, and methods, procedures, and techniques for the symptomatic control of pain are discussed.