Dysfunction of the magnocellular stream in Alzheimer's disease evaluated by pattern electroretinograms and visual evoked potentials.
Ferdinando Sartucci,D Borghetti,Tommaso Bocci,L. Murri,Paolo Orsini,Vittorio Porciatti,Nicola Origlia,Luciano Domenici,Luciano Domenici +8 more
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TLDR
The hypothesis that the impairment of the PERGs and VEPs arising from the magnocellular streams of visual processing may indicate a primary dysfunction of the M-pathways in AD is supported.About:
This article is published in Brain Research Bulletin.The article was published on 2010-05-31 and is currently open access. It has received 66 citations till now. The article focuses on the topics: Parvocellular cell & Contrast (vision).read more
Citations
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The Eye As a Biomarker for Alzheimer's Disease.
Jeremiah K.H. Lim,Qiao-Xin Li,Zheng He,Algis J. Vingrys,Vickie H. Y. Wong,Nicolas Currier,Jamie Mullen,Bang V. Bui,Christine T. O. Nguyen +8 more
TL;DR: The development of ocular biomarkers can have far implications in the discovery of treatments which can improve the quality of lives of patients, and potential future avenues of research in this area are explored.
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Structural and Functional Impairment of the Retina and Optic Nerve in Alzheimer’s Disease
Marilita M Moschos,Ioannis Markopoulos,Irini Chatziralli,Alexandros Rouvas,Sokratis G. Papageorgiou,Ioannis Ladas,Dimitrios Vassilopoulos +6 more
TL;DR: It is shown that in patients with AD, even without visual failure there was a decrease in macular and RNFL thickness, as well as a decrease of the electrical activity of the macula.
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Vision function abnormalities in Alzheimer disease
TL;DR: Findings from studies in the past 20 years of visual system abnormalities in AD are summarized and focus on findings that may be of more practical interest to the ophthalmologist.
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The optic nerve: a "mito-window" on mitochondrial neurodegeneration.
TL;DR: An overview of optic nerve pathology in these different clinical settings is provided, and the possible mechanisms involved in the pathogenesis of optic atrophy are reviewed, to suggest a model of general value for the field of neurodegeneration.
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Visuospatial Perception: An Emerging Biomarker for Alzheimer's Disease
TL;DR: The diagnostic scope of monitoring the brain activation correlates of VSP processing in AD is discussed in terms of the key advantages of utilizing VSP-related deficits in AD for early detection and longitudinal tracking of AD.
References
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Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
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Population-based norms for the mini-mental state examination by age and educational level
TL;DR: Results presented should prove to be useful to clinicians who wish to compare an individual patient's MMSE scores with a population reference group and to researchers making plans for new studies in which cognitive status is a variable of interest.
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Optical and retinal factors affecting visual resolution.
F. W. Campbell,D G Green +1 more
TL;DR: An improved version of the well-known interference fringe technique which theoretically allows a sinusoidal pattern of very high contrast to be formed directly on the retina to be obtained without prior modification by the optics of the eye is reported.
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How parallel are the primate visual pathways
TL;DR: This proposal that the cortical and subcortical pathways are continuous, so that distinct channels of information that arise in the retina remain segregated up to the highest levels of visual cortex has far-reaching implications for the understanding of the functional organization of the visual system.
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Visual Processing in Monkey Extrastriate Cortex
TL;DR: Three recent developments that have yielded insight into information processing and flow within extrastriate cortex are focused on.