Dysplastic nevus syndrome: A phenotypic association of sporadic cutaneous melanoma
TLDR
This paper represents the first description of this form of dysplasia in non‐familial melanoma and suggests that these patients represent a distinctive syndrome, the Dysplastic Nevus Syndrome (DNS), and that they are at increased risk for development of primary cutaneous malignant melanoma.Abstract:
Clinical photographs of 79 prospectively studied cases of non-familial cutaneous malignant melanoma were reviewed; special attention was directed to the distribution pattern of coexistent melanocytic lesions. A group of 15 patients had moles on the covered buttock area. Seven of these patients had large clinically atypical nevi, and biopsies of these nevi showed severe melanocytic dysplasia. Residual elements of melanocytic dysplasia were identified in five of the primary melanomas in this group of patients. It is suggested that these patients represent a distinctive syndrome, the Dysplastic Nevus Syndrome (DNS) and that they are at increased risk for development of primary cutaneous malignant melanoma. The clinically and histologically distinctive dysplastic nevi of these patients are identical to the precursor lesion for melanoma that we have previously described in a familial context, the B-K mole syndrome. This paper represents the first description of this form of dysplasia in non-familial melanoma.read more
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Journal ArticleDOI
The Genetic Evolution of Melanoma from Precursor Lesions
A. Hunter Shain,Iwei Yeh,Ivanka Kovalyshyn,Aravindhan Sriharan,Eric Talevich,Alexander Gagnon,Reinhard Dummer,Jeffrey P. North,Laura B. Pincus,Beth S. Ruben,William Rickaby,Corrado D’Arrigo,Alistair Robson,Boris C. Bastian +13 more
TL;DR: The succession of genetic alterations during melanoma progression was defined, showing distinct evolutionary trajectories for different melanoma subtypes, and an intermediate category of melanocytic neoplasia was identified, characterized by the presence of more than one pathogenic genetic alteration and distinctive histopathological features.
Journal ArticleDOI
High Risk of Malignant Melanoma in Melanoma-Prone Families with Dysplastic Nevi
Mark H. Greene,Wallace H. Clark,Margaret A. Tucker,Kenneth H. Kraemer,David E. Elder,Mary C. Fraser +5 more
TL;DR: It is confirmed that dysplastic nevi are clinical markers of high risk for, and precursors of, hereditary melanoma, and a known precursor of familial melanoma.
Journal ArticleDOI
Clinically Recognized Dysplastic Nevi: A Central Risk Factor for Cutaneous Melanoma
Margaret A. Tucker,Allan C. Halpern,Elizabeth A. Holly,Patricia Hartge,David E. Elder,Richard W. Sagebiel,DuPont Guerry,Wallace H. Clark +7 more
TL;DR: On the basis of nevus number and type, clinicians can identify a population at high risk of this epidemic cancer for screening and intervention and confer substantial risk for melanoma.
Journal ArticleDOI
Acquired precursors of cutaneous malignant melanoma. The familial dysplastic nevus syndrome.
Mark H. Greene,Wallace H. Clark,Margaret A. Tucker,David E. Elder,Kenneth H. Kraemer,DuPont Guerry,William K. Witmer,Jean Thompson,Isabel Matozzo,Mary C. Fraser +9 more
TL;DR: The incidence of cutaneous malignant melanoma is rising rapidly throughout the world and the most current data from the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) sy...
Journal ArticleDOI
Personal risk-factor chart for cutaneous melanoma
TL;DR: Information from a case-control study of all patients with cutaneous malignant melanoma first diagnosed in Scotland in 1987 has been used to derive a personal risk-factor chart that can be used by both the medical profession and the general public.
References
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Journal ArticleDOI
Origin of familial malignant melanomas from heritable melanocytic lesions. 'The B-K mole syndrome'.
TL;DR: The clinical and histological features of the B-K mole syndrome have been designated and atypical melanocytic hyperplasia, lymphocytic infiltration, delicate fibroplasia and new blood vessels that occur within a compound nevus or de novo are described.
Book ChapterDOI
The sequential analysis of cancer development.
Emmanuel Farber,Ross Cameron +1 more
TL;DR: This chapter reviews the sequence of cellular and other changes during cancer development in selected sites in experimental animals and in humans and highlights the similarities and differences among the carcinogenic processes.
Journal ArticleDOI
Familial atypical multiple mole-melanoma syndrome.
TL;DR: Transmission of the cutaneous phenotype in the subject family, and in several others currently under investigation, shows an inheritance pattern consistent with a simple autosomal dominant factor.
Journal ArticleDOI
Giant Pigmented Nevi, Melanoma, and Leptomeningeal Melanocytosis: A Clinical and Histopathological Study
TL;DR: Review of tissue and clinical material strongly suggests that malignancy, when it does occur, is not always related to an epithelial origin, and considers giant pigmented nevi and neurofibromatosis to be separate and distinct entities.