Journal ArticleDOI
Effect of a long-term treatment with 1,25-dihydroxyvitamin D3 on osteocalcin in postmenopausal osteoporosis.
TLDR
Serum bone Gla-protein (BGP or osteocalcin) was measured in 25 women with histologically confirmed postmenopausal osteoporosis before and during long-term treatment with 1 μg/day of 1,25-dihydroxyvitamin D3(1,25(OH)2D3) to determine a specific marker of bone formation.Abstract:
Serum bone Gla-protein (BGP or osteocalcin) was measured in 25 women with histologically confirmed postmenopausal osteoporosis before and during long-term treatment with 1 microgram/day of 1,25-dihydroxyvitamin D3(1,25(OH)2D3). Basal serum BGP was significantly lower in osteoporotic women (3.8 +/- 1.4 ng/ml) than in age-matched controls (6.8 +/- 2.0 ng/ml). During 1,25(OH)2D3 therapy serum BGP increased so that the mean of the values observed on treatment (4.8 +/- 1.5) was significantly higher than the mean basal value. It is known that BGP synthesis is stimulated by 1,25(OH)2D3 and that serum BGP is a specific marker of bone formation; therefore, it is possible that the low basal levels of osteocalcin we observed were related to the low serum 1,25(OH)2D concentrations reported in osteoporotic women and that the increase in BGP levels observed under 1,25(OH)2D3 treatment was a consequence of osteoblast stimulation.read more
Citations
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Journal ArticleDOI
Calcitriol Treatment Is Not Effective in Postmenopausal Osteoporosis
Susan M. Ott,Charles H. Chesnut +1 more
TL;DR: Calcitriol is not an effective treatment for established postmenopausal osteoporosis, but renal function was not worse than in the placebo group.
Journal ArticleDOI
Calcitriol in the treatment of postmenopausal osteoporosis
TL;DR: Calcitriol increased bone mineral density by decreasing bone resorption, but not by increasing bone formation, and it is possible that bone formation can be increased by achieving higher serum levels of the drug, whereas complications may be avoided by using a non-oral route of administration.
Journal ArticleDOI
Osteocalcin: diagnostic methods and clinical applications.
TL;DR: How various immunoassays for osteocalcin may contribute to the wide variation of published values and suggests approaches for the development of standardized assays are discussed.
Journal ArticleDOI
Osteocalcin and myoglobin removal in on-line hemodiafiltration versus low- and high-flux hemodialysis.
Francisco Maduell,Victor Navarro,Ma Carmen Cruz,Eduardo Torregrosa,Daniel Garcia,Victoria Simon,Jose Antonio Ferrero +6 more
TL;DR: LF-HD does not seem to remove solutes with a molecular weight greater than 5,800 daltons, and OL-HDF provides marked enhancement of convection volume and enables a significant increase in osteocalcin and beta2-microglobulin removal.
Journal ArticleDOI
Bone changes occurring early after cessation of ovarian function in beagle dogs: A histomorphometric study employing sequential biopsies
TL;DR: The results point to an early phase of initiation of bone loss related to hyperresorption followed by a maintenance phase of low bone mass ascribable to an osteoblastic insufficiency after cessation of ovarian function.
References
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Journal ArticleDOI
Intestinal Calcium Absorption and Serum Vitamin D Metabolites in Normal Subjects and Osteoporotic Patients: EFFECT OF AGE AND DIETARY CALCIUM
TL;DR: The data suggest that inadequate metabolism of 25-OH-D to 1,25(OH)(2)D contributes significantly to decreased calcium absorption and adaptation in both osteoporotic patients and elderly normal subjects.
Journal ArticleDOI
Characterization of a gamma-carboxyglutamic acid-containing protein from bone.
TL;DR: The identity of gamma-carboxyglutamic acid in the bovine protein was established by mass spectroscopy on the unknown amino acid isolated from alkaline hydrolysates.
Journal ArticleDOI
Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue
TL;DR: These findings may implicate vitamin K metabolism in normal bone development and suggest a role for the gamma-carboxyglutamate-rich protein in regulation of calcium salt deposition in mineralized tissues.
Journal ArticleDOI
Serum bone gla-protein: a specific marker for bone formation in postmenopausal osteoporosis
TL;DR: Serum BGP appears to be a specific marker for bone formation and can predict the histological profile in PMO and should be valuable in assessing the effects of treatments that increase bone formation.
Journal ArticleDOI
New biochemical marker for bone metabolism. Measurement by radioimmunoassay of bone GLA protein in the plasma of normal subjects and patients with bone disease.
TL;DR: Plasma BGP was increased in patients with Paget's disease of bone, bone metastases, primary hyperparathyroidism, renal osteodystrophy, and osteopenia and it was observed that patients with liver disease had normal plasma BGP despite increased plasma AP, a reflection of the lack of specificity of AP measurements for bone disease.
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