Open AccessJournal Article
Effect of Cnidoscolous aconitifolius (Miller) I.M. Johnston leaf extract on reproductive hormones of female rats
Musa Toyin Yakubu,Musbau Adewumi Akanji,Adenike Temidayo Oladiji,Abdulwaheed Olajide Olatinwo,Bamidele Victor Owoyele,TO Sunmonu +5 more
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TLDR
The alterations in the female rat reproductive hormones by the Cnidoscolous aconitifolius leaf extract are indications of adverse effect on the maturation and ovulation of follicles, Consequently, the extract may impair fertility and conception in female rats.Abstract:
Background: The increase in the rate of infertility in women has prompted the need to search for plants with antifertility potentials. Objective: The effect of administration of aqueous extract of Cnidoscolous aconitifolius leaves for seven days on reproductive hormones of female Wistar rats was investigated. Materials and Methods: Sixty female albino rats were grouped into four (A, B, C and D) of 15 each. Group A (the control) received orally 6.5 ml kg -1 body weight of distilled water on daily basis for 7 days. Groups B, C and D were treated like the control except that they received 250, 500 and 1000 mg kg -1 body weight of the extract. Results: Phytochemical screening of the extract revealed the presence of alkaloids, saponins, phenolics, tannins, flavonoids, anthraquinones, phlobatannins and triterpenes. Administration of the extract produced significant increase (p<0.05) in the serum prolactin concentration whereas those of estradiol, progesterone, follicle stimulating and luteinizing hormones were significantly reduced. Conclusion: The alterations in the female rat reproductive hormones by the extract are indications of adverse effect on the maturation and ovulation of follicles. Consequently, the extract may impair fertility and conception in female rats. Thus, the Cnidoscolous aconitifolius leaf extract may be explored as a female contraceptive.read more
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A Textbook of Pharmacognosy
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Amelioration of carbon tetrachloride-induced hepatotoxicity and haemotoxicity by aqueous leaf extract of Cnidoscolus aconitifolius in rats
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Antifertility Activity of Medicinal Plants on Reproductive system of Female Rat
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Screening of Bioactivities and Toxicity of Cnidoscolus quercifolius Pohl
Paulo Fernando Machado Paredes,Fábio Roger Vasconcelos,Raquel Teixeira Terceiro Paim,Márcia Maria Mendes Marques,Selene Maia de Morais,Sandra Machado Lira,Isabel Desidério Braquehais,Ícaro Gusmão Pinto Vieira,Francisca Noélia Pereira Mendes,Maria Izabel Florindo Guedes +9 more
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