Journal ArticleDOI
Effect of Human Leukocyte Interferon on Hepatitis B Virus Infection in Patients with Chronic Active Hepatitis
Harry B. Greenberg,Richard B. Pollard,Larry I. Lutwick,Peter B. Gregory,William S. Robinson,Thomas C. Merigan +5 more
TLDR
Parenteral interferon therapy was associated with a rapid and reproducible fall in all Dane-particle markers in four patients with chronic hepatitis B infection and chronic active hepatitis and may be useful in limiting carrier infectivity or eradicating chronic infection.Abstract:
Four patients with chronic hepatitis B infection and chronic active hepatitis were treated with human leukocyte interferon. Three of them had consistently elevated levels of circulating Dane-particle markers, including Dane-particle-associated DNA polymerase activity, hepatitis B core antigen and Dane-particle-associated DNA. Parenteral interferon administration at a dosage between 6.0 X 10(3) and 17 X 10(4) U per kilogram per day was associated with a rapid and reproducible fall in all Dane-particle markers in the three patients. The suppressive effect was transient when the interferon was given for 10 days or less but appeared to be more permanent when administration was prolonged for a month or more. In addition, long-term interferon therapy was associated with a marked fall in hepatitis B surface antigen in two of three patients and a disappearance of e antigen in two of two patients. Interferon may be useful in limiting carrier infectivity or eradicating chronic infection.read more
Citations
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Journal ArticleDOI
Hepatitis B virus infection.
TL;DR: This review addresses many aspects of HBV infection, including the role of the immune system in determining the outcome of clinical infection, recent developments in molecular studies of the virus, and new treatments capable of eradicating chronic infection.
Journal ArticleDOI
Interferons at age 50: past, current and future impact on biomedicine.
Ernest C. Borden,Ganes C. Sen,Gilles Uzé,Robert H. Silverman,Richard M. Ransohoff,Graham R. Foster,George Stark Stark +6 more
TL;DR: The goal is to offer a molecular and clinical perspective that will enable IFNs or their TLR agonist inducers to reach their full clinical potential.
Journal ArticleDOI
Hepatitis B Virus Infection
TL;DR: More effective and less resistance-prone antiviral agents are now available to treat hepatitis B virus (HBV) infection as mentioned in this paper, which is important, given the evidence linking high-level HBV replication and the late consequences of chronic HBV infection.
Journal ArticleDOI
Management of hepatitis B: 2000--summary of a workshop.
TL;DR: The authors in this paper provided a summary of the conference along with concluding recommendations on management of chronic hepatitis B, which is a preventable disease and a safe and effective vaccine has been available for almost 20 years.
Journal ArticleDOI
Shared and Distinct Functions of Type I and Type III Interferons.
TL;DR: A model wherein type III IFNs serve as a front-line defense that controls infection at epithelial barriers while minimizing damaging inflammatory responses, reserving the more potent type I IFN response for when local responses are insufficient is discussed.
References
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Journal ArticleDOI
Vertical transmission of hepatitis B antigen in Taiwan.
TL;DR: It is indicated that vertical transmission from carrier mothers frequently occurs, at least in Taiwan, and may partially explain Taiwan's high prevalence of HB5 Ag.
Journal ArticleDOI
Virus-like particles in serum of patients with australia-antigen-associated hepatitis
TL;DR: Virus-like particles about 42 nm in diameter have been found in multiple serum specimens from three Australia-antigen-positive hepatitis patients, and it is suggested that these particles may be complete virus and that the much more numerous 22 nm.
Journal ArticleDOI
DNA polymerase associated with human hepatitis B antigen.
P M Kaplan,P M Kaplan,P M Kaplan,Richard L. Greenman,Richard L. Greenman,Richard L. Greenman,John L. Gerin,John L. Gerin,John L. Gerin,Robert H. Purcell,Robert H. Purcell,Robert H. Purcell,William S. Robinson,William S. Robinson,William S. Robinson +14 more
TL;DR: DNA polymerase activity was detected in each of eight preparations of concentrated human hepatitis B antigen (HBAg) rich in Dane particles prepared by high-speed centrifugation of antigen-positive human plasma and in none of seven control preparations prepared in the same way from HBAg-negative plasma.
Journal ArticleDOI
E Antigen and Anti-E in the Serum of Asymptomatic Carrier Mothers as Indicators of Positive and Negative Transmission of Hepatitis B Virus to Their Infants
TL;DR: E antigen may be used as an indicator of transmission, and antibody to e as that of absence of transmission of hepatitis B virus from carrier mothers to children, according to results of testing of serum samples of 23 pregnant women.
Journal ArticleDOI
Hemagglutination Assay for Antigen and Antibody Associated with Viral Hepatitis
Girish N. Vyas,N. R. Shulman +1 more
TL;DR: The hemagglutination test has the sensitivity and rapidity of the best tests available, is simpler to perform, and lends itself to large-scale screening of blood donors.