Journal ArticleDOI
Effect of temperature and moisture on the miscibility of amorphous dispersions of felodipine and poly(vinyl pyrrolidone)
Patrick J. Marsac,Patrick J. Marsac,Alfred C. F. Rumondor,David E. Nivens,Umesh S. Kestur,Lia Stanciu,Lynne S. Taylor +6 more
TLDR
It appears that felodipine-PVP solid dispersions are susceptible to moisture-induced immiscibility when stored at a relative humidity >or=75%.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 2010-01-01. It has received 183 citations till now. The article focuses on the topics: Amorphous solid & Differential scanning calorimetry.read more
Citations
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Journal ArticleDOI
Evaluation of amorphous solid dispersion properties using thermal analysis techniques.
Jared A. Baird,Lynne S. Taylor +1 more
TL;DR: Although differential scanning calorimetry is the most widely used thermal analytical technique applied to the characterization of amorphous solid dispersions, there are many established and emerging techniques which have been shown to provide useful information.
Journal ArticleDOI
Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery - An update.
TL;DR: An updated review of nanocrystal and amorphous solid dispersion techniques primarily for orally delivered medicaments is provided along with marketed product evaluations and a survey of commercially relevant scientific literature.
Journal ArticleDOI
Melt extrusion with poorly soluble drugs
TL;DR: This review assesses the utility of ME as a means of enhancing solubility of poorly soluble drugs/chemicals and highlights the potential advantages of employing a fusion of techniques, including pharmaceutical co-crystals and spray drying/solvent evaporation, facilitating the design of formulations of API exhibiting specific physico-chemical characteristics.
Journal ArticleDOI
Modification of physicochemical characteristics of active pharmaceutical ingredients and application of supersaturatable dosage forms for improving bioavailability of poorly absorbed drugs.
TL;DR: This review discusses strategies for overcoming physicochemical problems during the development at the preformulation and formulation stages with emphasis on overcoming the most typical problem, low solubility.
Journal ArticleDOI
Comparison of Electrospun and Extruded Soluplus®-based Solid Dosage Forms of Improved Dissolution
Zsombor Kristóf Nagy,Attila Balogh,Balázs Vajna,Attila Farkas,Gergő Patyi,Áron Kramarics,György Marosi +6 more
TL;DR: Electrospinning and extrusion of a poorly water-soluble active pharmaceutical ingredient were used to improve its dissolution, which is a major challenge in the field of pharmaceutical technology, and resulted in significantly improved dissolution.
References
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Journal ArticleDOI
Rate of Nucleation in Condensed Systems
D. Turnbull,J. C. Fisher +1 more
TL;DR: On the basis of the nucleation theory developed by Volmer, Becker, and co-workers, and the theory of absolute reaction rates, an expression for the absolute rate of nucleation in condensed systems was derived in this paper.
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Introduction to Polymers
Robert J. Young,Chan I. Chung +1 more
TL;DR: In this article, the authors discuss the history of polymers and their application in the field of chemical engineering, including the origins of polymer science and the Polymer Industry, as well as a discussion of the role of elastic deformation in polymers.
Journal ArticleDOI
Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more
TL;DR: A comparison of the carbonyl stretching region of γ indomethacin, known to form carboxylic acid dimers, with that of amorphous indometHacin indicated that the amorphously phase exists predominantly as dimers.
Journal ArticleDOI
The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids.
Bruno C. Hancock,George Zografi +1 more
TL;DR: It was found that there is a rapid initial reduction in the glass transition temperature from the dry state as water is absorbed, followed by a gradual leveling off of the response at higher water contents, indicating that water acts as a plasticizer in a way similar to that of other small molecules and not through any specific or stoichiometric interaction process(es).
Book
Solubility and Solubilization in Aqueous Media
TL;DR: In this paper, the authors provide a working knowledge of the various means of controlling the solubility or dissolution rate of a drug or other solute in an aqueous medium, including buffers, co-solvents, surfactants, and complexants.
Related Papers (5)
Spectroscopic characterization of interactions between PVP and indomethacin in amorphous molecular dispersions.
Lynne S. Taylor,George Zografi +1 more