Journal ArticleDOI
Effect of the delta sleep-inducing peptide (DSIP) on the sleep-wakefulness cycle of cats.
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TLDR
The results suggest that, in the cat, appropriate intravenous doses of DSIP have a facilitatory action on both NREM and REM sleep, an effect which is absent after higher doses.About:
This article is published in Neuroscience Letters.The article was published on 1978-08-01. It has received 44 citations till now. The article focuses on the topics: Non-rapid eye movement sleep & Delta sleep-inducing peptide.read more
Citations
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Delta-sleep-inducing peptide (DSIP): An update
Markus V. Graf,Abba J. Kastin +1 more
TL;DR: Immunohistochemical as well as radioimmunochemical studies provided further insights into the natural occurrence of the nonpeptide and the distribution of DSIP-like material in the body, suggesting possible relations of the peptide to certain diseases.
Journal ArticleDOI
Delta-sleep-inducing peptide (DSIP): A review
TL;DR: One of the sleep-peptides, DSIP, was shown to be a nonapeptide of MW 849 and to induce mainly delta-sleep in rabbits, rats, mice, and humans, whereas in cats, the effect on REM sleep was more pronounced.
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Increased sleep following intracerebroventricular injection of the delta sleep-inducing peptide in rats.
Reidun Ursin,Mette Voldby Larsen +1 more
TL;DR: Synthetic delta sleep-inducing peptide was injected intracerebroventricularly into rats in a dose of 7 nmol/kg and a significant, 20% increase in total slow wave sleep was found in the DSIP-injected rats, compared to a baseline recording following a sham injection procedure.
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Localization of neurons containing immunoreactive delta sleep-inducing peptide in the rat brain: an immunocytochemical study.
S.C. Feldman,Abba J. Kastin +1 more
TL;DR: The widespread distribution of the peptide, the lack of demonstrable immunoreactive fiber tracts, and the presence of these neurons in areas known to contain aminergic and peptidergic neurons raises the possibility that neurons containing delta sleep-inducing peptide may exert their effect by projecting directly into blood vessels and/or interacting with neurons in their immediate vicinity.
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Comparison of the effects of two ‘sleep’ peptides, delta sleep-inducing peptide and arginine-vasotocin, on single neurons in the rat and rabbit brain stem
J.R. Normanton,J.P. Gent +1 more
TL;DR: It is concluded that both 'sleep' peptides have similar actions on central neurons and that they are active in both rats and rabbits and no evidence was found to suggest a common mechanism of action for both substances.
References
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Extraction of sleep-promoting factor S from cerebrospinal fluid and from brains of sleep-deprived animals.
TL;DR: Sleep-promoting factor (factor S) was extracted, partially purified, and concentrated from cerebrospinal fluid and from acid-acetone extracts of brain stem anc cortex of sleep-deprived goats and sheep and assayed by decrease in nocturnal locomotor activity of rats and by duration and amplitude of slow-wave cortical EEG in rabbits.
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Characterization of a delta-electroencephalogram (-sleep)-inducing peptide.
TL;DR: Only the delta-sleep-inducing peptide (snythetic) showed significant and specific enhancement/induction of delta and spindle electroencephalogram patterns.
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A naturally occurring delta-EEG enhancing nonapeptide in rabbits. X. Final isolation, characterization and activity test.
TL;DR: The purpose of this comparison was to test the effect of the specific delta-EEG enhancing peptide against a corresponding unspecific nonapeptide-“analogue”.
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Delta sleep-inducing peptide (DSIP): EEG and motor activity in rabbits following intravenous administration.
TL;DR: EEG and behavioral effects confirmed that DSIP also induces, when intravenously injected, orthodox slow wave sleep.
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The delta sleep inducing peptide (DSIP). Comparative properties of the original and synthetic nonapeptide
TL;DR: Both the original and the synthetic nonapeptide Trp-Ala-Gly-Glys-Asp- ala-Ser-G ly-Glu enhance, in recipient rabbits, spindle and delta EEG activity as in orthodox slow wave sleep.