Journal ArticleDOI
Effect of traditional Chinese medicine Shu-Mai-Tang on attenuating TNFα-induced myocardial fibrosis in myocardial ischemia rats
TLDR
It is suggested that SMT could anti-inflammation-induced myocardial fibrosis and reverse LV remodeling in MI rats, and the mechanism may be related to the effect of SMT on inhibiting p38 MAPK signaling pathway.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2008-06-19. It has received 23 citations till now. The article focuses on the topics: Myocardial fibrosis & Ventricular remodeling.read more
Citations
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Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2.
TL;DR: Berberine reduces oxidative stress and vascular inflammation, and suppresses atherogenesis via a mechanism that includes stimulation of AMPK-dependent UCP2 expression.
Journal ArticleDOI
Insects: an underrepresented resource for the discovery of biologically active natural products.
Lauren Seabrooks,Longqin Hu +1 more
TL;DR: An overview of current traditional medicinal applications of insects and characterization of isolated biologically active molecules starting from approximately 2010 is presented.
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Cardioprotective effects of the YiQiFuMai injection and isolated compounds on attenuating chronic heart failure via NF-κB inactivation and cytokine suppression.
TL;DR: The results suggested that NF-κB inactivation and cytokine suppression might be one of the main mechanisms of YQFM that caused ameliorative effects in CHF rats, and the major constituents of ginsenosides were identified playing a key role in the treatment of CHF.
Journal ArticleDOI
Effects and Mechanisms of Chinese Herbal Medicine in Ameliorating Myocardial Ischemia-Reperfusion Injury
TL;DR: This review highlights recent studies which are focused on elucidating the cellular and molecular mechanisms using extracted compounds, single herbs, or herbal formulations in experimental settings in the treatment of myocardial infarction.
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Anti-myocardial ischemia effect of Syringa pinnatifolia Hemsl. by inhibiting expression of cyclooxygenase-1 and -2 in myocardial tissues of mice
Yuan Cao,Jing Wang,Guozhu Su,Yan Wu,Ruifeng Bai,Qian Zhang,Xiao-Li Gao,Chun Li,Suyile Chen,Pengfei Tu,Xingyun Chai +10 more
TL;DR: Intragastric pretreatment with SP produced a dose-dependent increase in cardiac function and substantial evidence to support the clinical application of SP is shown and indicates that such medicine has great potential for treating ischemia-induced heart disease.
References
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Journal ArticleDOI
Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms.
Nelson B. Schiller,P. M. Shah,Michael H. Crawford,Anthony N. DeMaria,Richard B. Devereux,Harvey Feigenbaum,H. Gutgesell,Nathaniel Reichek,David J. Sahn,Ingela Schnittger +9 more
TL;DR: It is the opinion that current technology justifies the clinical use of the quantitative two-dimensional methods described in this article and the routine reporting of left ventricular ejection fraction, diastolic volume, mass, and wall motion score.
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Signalling pathways of the TNF superfamily: a double-edged sword.
TL;DR: Two different tumour-necrosis factors, first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice, and blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases.
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Molecular Mechanisms of Myocardial Remodeling
TL;DR: This review focuses only on permanent modifications in relation to clinical dysfunction in cardiac remodeling secondary to myocardial infarction and/or arterial hypertension and includes a special section on the senescent heart, since CR is mainly a disease of the elderly.
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Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α
Debora D. Bryant,Lisa Becker,James A. Richardson,John M. Shelton,Fátima Franco,Ronald M Peshock,Marita Thompson,Brett P. Giroir +7 more
TL;DR: It is indicated that production of TNF-alpha by cardiac myocytes is sufficient to cause severe cardiac disease and support a causal role for this cytokine in the pathogenesis of human cardiac disease.
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TIMPs as multifacial proteins
TL;DR: The multiple activities of TIMPs in vivo and in vitro are detailed and their implication in physiological and pathological processes are reported and itemized the different signalling pathways they induced.