Journal ArticleDOI
Effect of various antidepressant drugs on the spontaneous firing rate of locu coeruleus and dorsal raphe neurons of the rat
TLDR
Results are in good agreement with the relative potencies of the tricyclic antidepressants for blocking the uptake of noradrenaline and serotonin into central and peripheral neurons.About:
This article is published in European Journal of Pharmacology.The article was published on 1979-08-01. It has received 114 citations till now. The article focuses on the topics: Desipramine & Mianserin.read more
Citations
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Journal ArticleDOI
The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment.
TL;DR: Treatment of depression in patients with CVD improves their dysphoria and other signs and symptoms of depression, improves quality of life, and perhaps even increases longevity.
Journal ArticleDOI
Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment: Implications for the Etiology and Therapy of Depression
TL;DR: The effects of long-term antidepressant treatment on biogenic amine metabolism and on various indexes of presynaptic and postsynaptic receptor function are evaluated to provide support for hypotheses of amine receptor abnormalities in depression and indicate the need for expanded studies ofAmine receptor function in patients.
Journal ArticleDOI
Central monoamines and their role in major depression
TL;DR: Blocking the somatodendritic 5-HT(1A) or nerve terminal alpha(2) receptors proved to increase the response rate in the treatment of major and treatment-resistant depression, providing further support to the assumption that the antidepressant effect results from the long-term adaptive changes in the monoamine auto- and heteroregulatory receptors.
Journal ArticleDOI
Sympathetic Nervous System Activity in Major Depression: Basal and Desipramine-Induced Alterations in Plasma Norepinephrine Kinetics
Richard C. Veith,Nancy Lewis,Oscar A. Linares,Robert F. Barnes,Murray A. Raskind,Enrique C. Villacres,M. Michele Murburg,E. Alexandra Ashleigh,Sonia Castillo,Elaine R. Peskind,Marcella Pascualy,Jeffrey B. Halter +11 more
TL;DR: The demonstration of SNS reactivation occurring with prolonged desipramine treatment is compatible with the theory that long-term treatment desensitizes CNS alpha 2-adrenergic receptors and emphasizes the value of examining the temporal course of responses to pharmacological challenges of neuroendocrine systems.
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The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments
TL;DR: Although there are some contradictions, the bulk of data suggests that antidepressant treatments work in the hippocampus by increasing and decreasing, respectively, serotonergic and noradrenergic neurotransmission.
References
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Journal Article
Evidence for the existence of monoamine-containing neurons in the central nervous system. i. demonstration of monoamines in the cell bodies of brain stem neurons.
Dahlstroem A,Fuxe K +1 more
Journal ArticleDOI
Dynamic response of chest wall and lung injuries in rabbits exposed to air shock waves of short duration.
Carl-Johan Clemedson,Joensson A +1 more
TL;DR: The chest walls of rabbits exposed to steep-fronted air shock waves of short duration produced by 50 g spherical charges of TNT were recorded by means of a mechano-electric motion transducer to study the correlation between the deformations of the chest and the damage inflicted to the underlying organs, especially the lungs.
Journal ArticleDOI
Sixth gaddum memorial lecture national institute for medical research, mill hill, january 1977
TL;DR: The topic of the lecture will be the presence of presynaptic receptors in noradrenergic nerve endings and their role in the regulation of the release of the neurotransmitter upon arrival of nerve impulses.
Related Papers (5)
Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: alpha-receptor mediation.
Torgny H. Svensson,Ted Usdin +1 more