Effectiveness of azelastine nasal solution in seasonal allergic rhinitis.
William W. Storms,D. S. Pearlman,Paul Chervinsky,J. Grossman,P. C. Halverson,J. J. Freitag,M. D. Widlitz +6 more
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TLDR
The results of this trial demonstrate that azelastine nasal solution provides an alternative to oral medication in the treatment of SAR and its rapid onset and prolonged duration of action in relieving rhinitis symptoms and advantages over currently marketed topical treatments make it a good choice for Treatment of SAR.Abstract:
Azelastine is a novel antiallergy medication currently under investigation for the treatment of allergic rhinitis and asthma. Pharmacologic studies in laboratory animals and in vitro model systems ...read more
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Allergic Rhinitis and Its Impact on Asthma
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Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis
Charles H. Banov,Phil Lieberman +1 more
TL;DR: This is the first demonstration of the efficacy of an antihistamine in the therapy of VMR in two double-blind, placebo-controlled clinical trials.
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References
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Inhibition of calcium ionophore (A23187)-stimulated histamine release from rat peritoneal mast cells by azelastine: implications for its mode of action.
TL;DR: The data suggest that azelastine inhibits A23187-stimulated histamine release by interfering with the influx of Ca2+ into the mast cells, which is antagonized by high concentrations of exogenous Ca2- ions.
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Inhibition of allergic histamine release by azelastine and selected antiallergic drugs from rabbit leukocytes.
TL;DR: Azelastine is a potent inhibitor of allergic histamine secretion from the leukocytes of ragweed-sensitized rabbits and is about 2, 4, 13 and greater than 200 times as effective as ketotifen, diphenhydramine, theophylline and DSCG, respectively.
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Inhibition of leukotriene (SRS-A)-mediated acute lung anaphylaxis by azelastine in guinea pigs.
TL;DR: Azelastine is an orally effective and long‐acting inhibitor of in vivo synthesis and/or release of leukotrienes and produced weak, inconsistent and nondose‐related antianaphylactic effects.
Journal ArticleDOI
Beneficial effects of propylene and polyethylene glycol and saline in the treatment of perennial rhinitis
TL;DR: It is demonstrated that wetting agents offer both subjective and objective improvement in the treatment of perennial rhinitis and merit consideration prior to (or along with) other agents with known systemic side effects.
Journal ArticleDOI
Efficacy of azelastine in perennial allergic rhinitis: clinical and rhinomanometric evaluation
Eli O. Meltzer,William W. Storms,William E. Pierson,Leo H. Cummins,H.Alice Orgel,James L. Perhach,George R. Hemsworth +6 more
TL;DR: Amelioration of most individual symptoms and a decrease in the total symptom scores were observed with both dosages of azelastine; greater improvement with 2 mg twice daily than with 1mg twice daily, was observed.
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