Journal ArticleDOI
Effects of aging and dementia upon recent visuospatial memory
Charles Flicker,Charles Flicker,Raymond T. Bartus,Raymond T. Bartus,Thomas H. Crook,Steven H. Ferris +5 more
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TLDR
Correlation analyses demonstrated that delayed spatial recall (as well as choice reaction time) is highly correlated with clinically evaluated global cognitive status, as well as with tests of verbal recall.About:
This article is published in Neurobiology of Aging.The article was published on 1984-12-01. It has received 123 citations till now. The article focuses on the topics: Recall & Cognitive decline.read more
Citations
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A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memory
TL;DR: There is no correlation between the three tests which argues for a multiple form of working memory, especially a spatial and a non-spatial one, and the level of discrimination in the spatial recognition test was significantly reduced compared to that of control.
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Age‐associated memory impairment: Proposed diagnostic criteria and measures of clinical change — report of a national institute of mental health work group
Thomas H. Crook,Raymond T. Bartus,Steven H. Ferris,Peter J. Whitehouse,Gene D. Cohen,Samuel Gershon +5 more
TL;DR: In this article, the authors proposed diagnostic criteria and measures of clinical change for age-associated memory impairment and developed a set of diagnostic criteria based on the report of a national institute of mental health work group.
Journal ArticleDOI
On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis.
TL;DR: A review of the current status of the cholinergic hypothesis in the context of continuing efforts to improve upon existing treatments for Alzheimer's disease and explores the role that animal models might continue to play as discussed by the authors.
Journal ArticleDOI
Impact of aging on hippocampal function: plasticity, network dynamics, and cognition.
TL;DR: Studies of the effects of aging on hippocampal anatomy, physiology, plasticity, and network dynamics may lead to a better understanding of age-related cognitive deficits, including deficits in the induction and maintenance of long-term potentiation and lower thresholds for depotentiation and long- term depression.
Journal ArticleDOI
Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence
TL;DR: Recent findings in humans indicate that antimuscarinic drugs do not model the deficits seen in AD, and attempts to develop cholinergic pharmacotherapies for these deficits in AD are based on questionable assumptions.
References
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The Global Deterioration Scale for assessment of primary degenerative dementia.
TL;DR: The authors describe a Global Deterioration Scale for the assessment of primary degenerative dementia and delineation of its stages and have used it successfully for more than 5 years and validated it against behavioral, neuroanatomic, and neurophysiologic measures in patients with primary degeneratives dementia.
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Short-term retention of individual verbal items.
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Category norms of verbal items in 56 categories A replication and extension of the Connecticut category norms
Journal ArticleDOI
Evaluating storage, retention, and retrieval in disordered memory and learning
Herman Buschke,P. Fuld +1 more
TL;DR: These new methods provide simultaneous analysis of storage, retention, and retrieval during verbal learning because they let the patient show learning by spontaneous retrieval without csnfounding by continual presentation.
Related Papers (5)
Short-term memory in the rhesus monkey: disruption from the anti-cholinergic scopolamine.
Raymond T. Bartus,H. R. Johnson +1 more