Journal ArticleDOI
On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis.
TLDR
A review of the current status of the cholinergic hypothesis in the context of continuing efforts to improve upon existing treatments for Alzheimer's disease and explores the role that animal models might continue to play as discussed by the authors.About:
This article is published in Experimental Neurology.The article was published on 2000-06-01. It has received 763 citations till now. The article focuses on the topics: Context (language use).read more
Citations
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The Cholinergic Hypothesis of Age and Alzheimer's Disease-Related Cognitive Deficits: Recent Challenges and Their Implications for Novel Drug Development
TL;DR: Cholinergic abnormalities may also contribute to noncognitive behavioral abnormalities as well as the deposition of toxic neuritic plaques in AD and cholinergic-based strategies will likely remain valid as one approach to rational drug development for the treatment of AD other forms of dementia.
Journal ArticleDOI
The cholinergic system in aging and neuronal degeneration.
Reinhard Schliebs,Thomas Arendt +1 more
TL;DR: Observed changes in the expression of NGF, its precursor proNGF, the high and low NGF receptors, trkA and p75NTR, respectively, changes in acetylcholine release, high-affinity choline uptake, as well as alterations in muscarinic and nicotinic acetyl choline receptor expression may contribute to the cholinergic dysfunction.
Journal ArticleDOI
Alzheimer's disease: Targeting the Cholinergic System
Talita H. Ferreira-Vieira,Isabella M. Guimaraes,Flavia Rodrigues da Silva,Fabiola M. Ribeiro +3 more
TL;DR: Synthesis of cholinergic neurons located in the basal forebrain, including the neurons that form the nucleus basalis of Meynert, are severely lost in Alzheimer’s disease, and drugs that act on the choline system represent a promising option to treat AD patients.
Journal ArticleDOI
Aging cognition: from neuromodulation to representation
TL;DR: A paradigm shift towards cross-level conceptions is needed in order to obtain an integrative understanding of cognitive aging phenomena that cuts across neural, information-processing, and behavioral levels, and empirical data at these different levels are reviewed.
Journal ArticleDOI
The Brain Metabolite Kynurenic Acid Inhibits α7 Nicotinic Receptor Activity and Increases Non-α7 Nicotinic Receptor Expression: Physiopathological Implications
Corey Hilmas,Edna F. R. Pereira,Manickavasagom Alkondon,Arash Rassoulpour,Robert Schwarcz,Edson X. Albuquerque +5 more
TL;DR: It is demonstrated that nAChRs are targets for KYNA and suggest a functionally significant cross talk between the nicotinic cholinergic system and the kynurenine pathway in the brain.
References
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Journal ArticleDOI
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
Raymond T. Bartus,Raymond T. Bartus,Reginald L. Dean,Bernard Beer,Bernard Beer,Arnold S. Lippa,Arnold S. Lippa +6 more
TL;DR: Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed and an attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature.
Journal ArticleDOI
Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.
Peter J. Whitehouse,Donald L. Price,Robert G. Struble,Arthur W. Clark,Joseph T. Coyle,Mahlon R. DeLong +5 more
TL;DR: Demonstration of selective degeneration of neurons of the nucleus basalis of Meynert represents the first documentation of a loss of a transmitter-specific neuronal population in a major disorder of higher cortical function and points to a critical subcortical lesion in Alzheimer's patients.
Journal ArticleDOI
Selective loss of central cholinergic neurons in alzheimer's disease
Peter Davies,A.J.F. Maloney +1 more
Journal ArticleDOI
Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
TL;DR: The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex and loss of this neuronal population may represent an anatomical correlate of the well‐documented cholinerential derangement in Alzheimer disease.
Related Papers (5)
Selective loss of central cholinergic neurons in alzheimer's disease
Peter Davies,A.J.F. Maloney +1 more