Journal ArticleDOI
Effects of intravenous phospholipid containing phosphatidyl serine on blood clotting with particular reference to the Russell's viper venom time.
J. F. Mustard,J. F. Mustard,J. F. Mustard,W. Medway,W. Medway,W. Medway,H. G. Downie,H. G. Downie,H. G. Downie,H. C. Rowsell,H. C. Rowsell,H. C. Rowsell +11 more
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Effects of Intravenous Phospholipid Containing Phosphatidyl Serine on Blood Clotting with Particular Reference to the Russell's Viper Venom Time is studied.Abstract:
Effects of Intravenous Phospholipid Containing Phosphatidyl Serine on Blood Clotting with Particular Reference to the Russell's Viper Venom Timeread more
Citations
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Journal ArticleDOI
A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation
TL;DR: Investigation of microsomes from arterial wall or fundus of stomach with platelet-rich plasma under various conditions shows that the enzyme which generates PGX can utilize endoperoxides liberated from platelets or added to the cuvette, thereby preventing, interrupting or reversing the process of platelet aggregation.
Journal ArticleDOI
Platelets and atherosclerosis.
TL;DR: It seems reasonable to regard these findings as support for the theory that blood coagulation, platelets and the accretion of blood elements on the endothelium are vitally concerned in the development of atherosclerosis.
Book ChapterDOI
The role of lipids in blood coagulation.
Aaron J. Marcus,Aaron J. Marcus +1 more
TL;DR: The role of lipids in blood coagulation was discussed in this paper, where it was shown that platelet lipoprotein is normally derived from the blood platelet and exerts a surface catalytic action on the plasma co-agulation proteins with which it may bind in the presence of calcium.
Journal ArticleDOI
Complexes of Prothrombin with Calcium Ions and Phospholipids
TL;DR: It was suggested that an optimal surface condition is required to bind reversibly prothrombin prior to conversion to thrombin, andAnticoagulant effects ascribed to acidic phospholipids may be due to irreversible binding of the clotting factors to lipid surfaces.
References
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Journal ArticleDOI
Microdetermination of plasma phospholipids by trichloroacetic acid precipitation.
D.B. Zilversmit,A.K. Davis +1 more
TL;DR: A method is presented in which plasma phospholipids can be determined in 0.2 ml of plasma, which is simpler and more rapid than methods involving the use of fat solvents.
Journal ArticleDOI
Chromatography of phosphatides on silicic acid impregnated paper
G.V. Marinetti,Elmer Stotz +1 more
Journal ArticleDOI
A correlation between surface charge and coagulant action of phospholipids.
TL;DR: The results show clearly the interdependence of both sign—positive or negative— and magnitude of enzyme and substrate interaction in any particular ionic environment.
Journal ArticleDOI
Phospholipid structure and thromboplastic activity. I. The phosphatide fraction active in recalcified normal human plasma.
TL;DR: The ability of a phosphatide to accelerate the coagulation rate appears to be associated with the formation of a finely dispersed colloidal particle with a negative charge on a phosphate group, and the presence of a proton-donor group.
Journal ArticleDOI
Dicumarol Therapy Some Effects on Platelets and Their Relationship to Clotting Tests
E. A. Murphy,J. F. Mustard +1 more
TL;DR: Comparison of platelet function in control periods and during Dicumarol administration shows that this drug lowers the adhesive index and prolongs the platelet clumping time to a highly significant degree and clotting time was the least efficient.