Journal ArticleDOI
Effects of L-tryptophan and restraint stress on hypothalmic and brain serotonin turnover, and pituitary TSH and prolactin release in rats
Reads0
Chats0
TLDR
Findings indicate that enhanced rates of serotonin turnover produced by L-tryptophan and physical restraint are associated with inhibition of TSH and stimulation of PRL release from the anterior pituitary.About:
This article is published in Life Sciences.The article was published on 1976-04-01. It has received 113 citations till now. The article focuses on the topics: Serotonin & Anterior pituitary.read more
Citations
More filters
Journal ArticleDOI
Relation of endogenous opioid peptides and morphine to neuroendocrine functions
TL;DR: Preliminary observations indicate that the EOP may increase serotonin and decrease dopamine metabolism in the hypothalamus, which could account for practically all of their effects on pituitary hormone secretion.
Journal ArticleDOI
Serotonin function in anxiety. II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects.
TL;DR: In this paper, the role of serotonin function in the development of panic anxiety was assessed in healthy subjects and agoraphobic and panic disorder patients with m-chlorophenylpiperazine (MCPP).
Journal ArticleDOI
Serotonergic function in obsessive-compulsive disorder. Behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers.
Eric Hollander,Concetta M. DeCaria,Anca Nitescu,Robert Gully,Raymond F. Suckow,Thomas B. Cooper,Jack M. Gorman,Donald F. Klein,Michael R. Liebowitz +8 more
TL;DR: Behavioral and neuroendocrine responses appeared divergent in patients following m-CPP but not following fenfluramine, and complex mechanisms involving multiple neurotransmitter and neuromodulator systems are suggested.
Journal ArticleDOI
Serotonin function in obsessive-compulsive disorder. A comparison of the effects of tryptophan and m-chlorophenylpiperazine in patients and healthy subjects.
Dennis S. Charney,Wayne K. Goodman,Lawrence H. Price,Scott W. Woods,Steven A. Rasmussen,George R. Heninger +5 more
TL;DR: The results lend only partial support to the hypothesis that 5-HT dysfunction may be linked to the pathophysiology of OCD and point to the need for the evaluation of other neurotransmitter systems in future investigations of OCD.
Journal ArticleDOI
Effects of serotonergic agonists and antagonists on corticotropin-releasing hormone secretion by explanted rat hypothalami
Aldo E. Calogero,Renato Bernardini,Andrew N. Margioris,Gyorgy Bagdy,William T. Gallucci,Peter J. Munson,Lawrence Tamarkin,Thomas P. Tomai,Linda S. Brady,Philip W. Gold,George P. Chrousos +10 more
TL;DR: The findings suggest that serotonin stimulates CRH secretion by explanted rat hypothalami and that this effect appears to be mediated mainly through a 5HT2 receptor mechanism.
References
More filters
Journal ArticleDOI
Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain
G. Curzon,A. R. Green +1 more
TL;DR: A rapid and sensitive method for measuring 5‐hydroxytryptamine and 5-hydroxyindoleacetic acid, using o‐phthalaldehyde and L‐cysteine, is presented, enabling both compounds to be measured in small areas of rat brain.
Journal ArticleDOI
The determination of tryptophan in plasma, liver, and urine.
TL;DR: The specificity of the method is such that, of the compounds tested, only tryptamine produces appreciable fluorescence: one tenth of the molar fluorescence of tryptophan.
Journal ArticleDOI
Studies in vivo on the relationship between brain tryptophan, brain 5‐ht synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and l‐tryptophan
TL;DR: It is suggested that when monoamine oxidase is inhibited and the rate of 5‐HT synthesis is increased, granular uptake and storage of 5-HT and other rate‐limiting mechanisms for 5‐ht inactivation are unable to prevent 5‐ HT 'spilling over’ to produce hyperactivity.
Journal ArticleDOI
The effects of precursor loading in the cerebral metabolism of 5‐hydroxyindoles
A. T. B. Moir,D. Eccleston +1 more
TL;DR: It is concluded that there are regional differences within brain in storage, turnover or metabolic fate of 5‐HT, and that turnover through the system is normally controlled by intracerebral tryptophan 5‐hydroxylase in both rats and dogs although there are differences between the species in the cerebral metabolism of5‐HT.
Journal ArticleDOI
Effects of prolactin and ergot alkaloids on the tubero-infundibular dopamine (DA) neurons.
T. Hökfelt,Kjell Fuxe +1 more
TL;DR: Using the Falck-Hillarp fluorescence technique, the effect of various hypophyseal hormones on the rate of depletion of catecholamines from certain central neuron systems was investigated.
Related Papers (5)
Effects of melatonin and serotonin on the release of FSH and prolactin.
Role of brain monoamines and histamine in regulation of anterior pituitary secretion.
R I Weiner,W F Ganong +1 more