Journal ArticleDOI
Effects of methionine-enkephalin and leucine-enkephalin compared with those of morphine on brainstem neurones in cat
J. P. Gent,J. H. Wolstencroft +1 more
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The findings of similar depressant actions of all three substances on brainstem neurones in the cat are reported, suggesting that these substances have activity in the central nervous system similar to that of morphine.Abstract:
Two new peptides, methionine-enkephalin (met-enkephalin) and leucine–enkephalin (leu-enkephalin), have been isolated from brain, identified and synthesised1. The interest in these compounds lies in their morphine-like activity which was recognised and tested by their action on isolated preparations from the peripheral nervous system. Since morphine is used for its central action in producing analgesia, it is important to investigate whether these substances have activity in the central nervous system similar to that of morphine. We report here the findings of similar depressant actions of all three substances on brainstem neurones in the cat.read more
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Brainstem Control of Spinal Pain-Transmission Neurons
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Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness.
TL;DR: The endogenous morphinomimetic brain peptides Met5-enkephalin and alpha-, beta-, and gamma-endorphins have been evaluated in rats after intracerebrospinal fluid injection and their potent and divergent responses to naturally occurring subtances suggest that alterations in their homeostatic regulation could have etiological significance in mental illness.
Journal ArticleDOI
Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques
Tony L. Yaksh,Thomas A. Rudy +1 more
TL;DR: Experimental approaches are resorted to which permit a detailed study of the interaction between narcotic analgetics and particular regions and/or functional systems within the central nervous system.
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Naloxone as a GABA antagonist: evidence from iontophoretic, receptor binding and convulsant studies.
TL;DR: Naloxone displaced 3H-GABA from receptor sites in rate forebrain and cerebellum, with similar low potency, and Diazepam, which protects mice against convulsions elicited by bicuculline, but not by strychnine, also protected mice against nalox one.
References
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Journal ArticleDOI
Identification of two related pentapeptides from the brain with potent opiate agonist activity
John J. Hughes,T. W. Smith,H. W. Kosterlitz,Linda A. Fothergill,B. A. Morgan,Howard R. Morris +5 more
TL;DR: The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl–Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides.
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Analgesia Induced by Electrical Stimulation of the Inferior Centralis Nucleus of the Raphe in the Cat
TL;DR: The results can be considered as evidence that the mechanism of analgesia from the inferior raphe nucleus is similar to that already described in the dorsal Raphe nucleus, which seems to be sustained by serotoninergic mechanisms.
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Convergence and interaction of afferent impulses on single units of reticular formation.
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Somatic stimuli, spinal pathways, and size of cutaneous fibers influencing unit activity in the medial medulary reticular formation ☆
TL;DR: Analysis of unit activity in the medial medullary reticular formation of unanesthetized, decerebrate and decereballate cats suggests that a neural population is part of a system subserving responses to noxious stimuli.
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Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brainstem
TL;DR: The findings support the concept of a physiological role for endogenous enkephalin in the central nervous system and compare these effects with those of morphine, and also of another narcotic analgesic, etorphine, which is considerably more potent.