Effects of physical restraint on leukemogenesis by Friend virus.
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The incidence of leukemia was reduced in the males, but not in the females, while the latent period was prolonged in both sexes, indicating sex dependency is characteristic of the stress response.Abstract:
The effects of physical restraint on the development of Friend erythroleukemia in ddY mice were examined. Restraint was applied by immobilizing the mice in wire cages. In both sexes there was a reduction in the weight of the whole body, thymus and spleen, though the food intake was not reduced. The incidence of leukemia was reduced in the males, but not in the females, while the latent period was prolonged in both sexes. This sex dependency is characteristic of the stress response.read more
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Chronic stress enhances progression of acute lymphoblastic leukemia via β-adrenergic signaling
Donald M. Lamkin,Erica K. Sloan,Erica K. Sloan,Erica K. Sloan,Ami J Patel,Beverley S Chiang,Matthew A. Pimentel,Jeffrey C.Y. Ma,Jeffrey C.Y. Ma,Jesusa M.G. Arevalo,Jesusa M.G. Arevalo,Kouki Morizono,Steven W. Cole +12 more
TL;DR: Results show that chronic stress can accelerate the progression of human pre-B ALL tumor load via a β-adrenergic signaling pathway that likely involves indirect regulation of ALL biology via alterations in the function of other host cell types such as immune cells or the bone marrow microenvironment.
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Metastasis and neuroendocrine system in stressed mice.
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Restraint of animals required for nose-only inhalation toxicologic studies suppresses pulmonary antibacterial defenses
TL;DR: It is demonstrated that immobilization of animals impairs pulmonary antibacterial defenses and raises questions whether other pulmonary biopsies, such as nose-only inhalation toxicologic studies, are affected.
References
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Lawrence S. Sklar,Hymie Anisman +1 more
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