Journal ArticleDOI
Effects of salmon calcitonin in postmenopausal osteoporosis: a controlled double-blind clinical study.
Gf Mazzuoli,Mario Passeri,Carlo Gennari,Salvatore Minisola,R. Antonelli,C. Valtorta,E Palummeri,Gf Cervellin,Stefano Gonnelli,Guido Francini +9 more
TLDR
It is shown that long-term salmon CT treatment may be of benefit in postmenopausal osteoporosis and that the effects of CT on bone mass may be due not only to the inhibition of bone resorption but also to the stimulation of bone formation.Abstract:
In this paper we present the results of a 12-month double-blind clinical multicenter study assessing the effects of synthetic salmon cacitonin (CT) administration in a group of white postmenopausal osteoporotic women. Treated patients were given 100 MRC units of synthetic salmon CT injected i.m. in the morning every other day. Control patients received a placebo injection. All patients received 500 mg of elementary calcium p.o., b.i.d. Bone mineral content (BMC) was measured at the extreme distal radius of the nondominant arm by a dual photon bone densitometer which utilizes two radionuclides,241Am and125I, with energies of about 60 keV and 30 keV respectively. Biochemical parameters of calcium-phosphorus metabolism were also measured. After 12 months of treatment a significant mean increment of BMC and nondialyzable OHPr/creatinine values and a significant decrease of total OHPr/creatinine values were observed in the treated group, while controls showed a significant decrease in BMC values. These results, together with the observation that in some patients the decrease in total OHPr/creatinine values was not accompanied by an increment of BMC, show that long-term salmon CT treatment may be of benefit in postmenopausal osteoporosis and that the effects of CT on bone mass may be due not only to the inhibition of bone resorption but also to the stimulation of bone formation.read more
Citations
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Effect of intermittent cyclical etidronate therapy on bone mass and fracture rate in women with postmenopausal osteoporosis.
TL;DR: Etidronate therapy for postmenopausal osteoporosis results in significant increases in vertebral bone mineral content and, after approximately one year of treatment, a significant decrease in the rate of new vertebral fractures.
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Endocrinology in aging
TL;DR: The principles of endocrinology in the geriatric population are described and the changes in specific glandular functions with aging are elaborate, including changes in glucose homeostasis, reproductive function, and calcium metabolism.
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Association of osteoporotic vertebral compression fractures with impaired functional status
Kenneth W. Lyles,Deborah T. Gold,Kathy M. Shipp,Carl F. Pieper,Salutario Martinez,Paul L. Mulhausen,Paul L. Mulhausen +6 more
TL;DR: Vertebral compression fractures are associated with significant performance impairments in physical, functional, and psychosocial domains in older women.
Journal ArticleDOI
Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women: a randomized controlled trial.
TL;DR: Calcium supplementation produces a sustained reduction in the rate of loss of total body BMD in healthy postmenopausal women.
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Renal bone disease 1990: an unmet challenge for the nephrologist.
TL;DR: A rational approach to the treatment of renal bone disease requires a basic understanding of the anatomic physiology of bone, the pathophysiologic effects of renal failure on mineral metabolism and bone, and the various available therapeutic modalities.
References
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Journal ArticleDOI
Long-term calcitonin therapy in postmenopausal osteoporosis
Helen E. Gruber,Joel L. Ivey,David J. Baylink,Meredith Matthews,Wil B. Nelp,Karen Sisom,Charles H. Chesnut +6 more
TL;DR: Iliac crest bone biopsies showed a significantly greater percent total bone area in treated compared to control patients at 2 years, and a significantly decreased percent resorbing surface in treated patients when evaluated by paired difference from baseline.
Journal ArticleDOI
Urinary polypeptides related to collagen synthesis
TL;DR: Four patients with hyperparathyroidism and osteitis fibrosa were studied before and after removal of a parathyroid adenoma, a period of transition from a predominance of bone collagen resorption to one of relatively increased bone collagen synthesis.
Journal ArticleDOI
Estimation of total body calcium from the bone mineral content of the forearm.
C. Christiansen,P. Rödbro +1 more
TL;DR: It is concluded that BMC measurements of the distal part of the forearm give an estimate of total body calcium.
Journal ArticleDOI
Bone density in women: A modified procedure for measurement of distal radial density
TL;DR: It is suggested that there is a unique role for single‐beam densitometric measurements of the radius, permitting the rapid and relatively inexpensive evaluation of large populations of women without requiring a visit to a medical center.
Journal ArticleDOI
Calcitonin and postmenopausal osteoporosis
TL;DR: The results indicate that postmenopausal osteoporosis is not caused by a deficiency of calcitonin and that the action of oestrogen therapy to prevent bone loss does not involve calcitonIn.