Journal ArticleDOI
Effects of sildenafil (Viagra™) administration on seminal parameters and post-ejaculatory refractory time in normal males
Antonio Aversa,Fernando Mazzilli,Tiziana Rossi,Michele Delfino,Andrea M. Isidori,Andrea Fabbri +5 more
TLDR
Results indicate that in normal subjects acute sildenafil treatment does not modify semen characteristics and has a positive influence over the resumption of erections following ejaculation in the presence of a continuous erotic stimulus.Abstract:
Sildenafil is a specific inhibitor of phosphodiesterase (PDE) type 5 and represents a powerful therapy for male erectile dysfunction (ED) of different aetiology. Recently, sildenafil has been shown to restore erections in temporary ED related to the need of semen collection for assisted reproductive techniques. In this study, we investigated whether sildenafil administration modifies seminal parameters and/or erectile function in normal healthy volunteers. In a double-blind, randomized, placebo-controlled, cross-over two period investigation we enrolled 20 healthy male volunteers (mean +/- SE age 32 +/- 0.5 years). Subjects were not using any medication for the 3 month period prior to the study and were engaged in a stable relationship with proven fertility. The effects of sildenafil (100 mg) on seminal parameters and erectile function after audiovisual sexual stimulation were evaluated by semen analysis and by colour-Duplex ultrasound (the Resistive Index) respectively. In all subjects, sildenafil caused no changes in seminal and erection parameters when compared to placebo. Interestingly, sildenafil administration led to a marked reduction of the post-ejaculatory refractory time (10.8 +/- 0.9 min versus 2.6 +/- 0.7 min for placebo and sildenafil respectively; P < 0.0001). These results indicate that in normal subjects acute sildenafil treatment does not modify semen characteristics and has a positive influence over the resumption of erections following ejaculation in the presence of a continuous erotic stimulus.read more
Citations
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Book ChapterDOI
Male Sexual Behavior
TL;DR: Major areas controlling sexual motivation and performance in males include the mesolimbic dopamine (DA) system, the medial preoptic area (MPOA), the amygdala, and the bed nucleus of the stria terminalis (BST).
Journal ArticleDOI
Efficacy of Sildenafil Citrate (Viagra) in Men with Premature Ejaculation
Chris McMahon,Bronwyn G. A. Stuckey,Morten Andersen,Kenneth Purvis,Nandan Koppiker,Scott Haughie,Mitra Boolell +6 more
TL;DR: Although IELT and VTS-ELT were not significantly improved, sildenafil increased confidence, the perception of ejaculatory control, and overall sexual satisfaction, and decreased the refractory time to achieve a second erection after ejaculation in men with PE.
Journal ArticleDOI
Correlation between ejaculatory and erectile dysfunction
TL;DR: The aim of this review article is to propose a new taxonomy of PE, which considers ED as an important factor of PE and vice versa.
Journal ArticleDOI
Position stand on androgen and human growth hormone use.
Jay R. Hoffman,William J. Kraemer,Shalender Bhasin,Thomas W. Storer,Nicholas A. Ratamess,G. Gregory Haff,Darryn S. Willoughby,Alan D. Rogol +7 more
TL;DR: The NSCA rejects the use of androgens and hGH or any performance-enhancing drugs on the basis of ethics, the ideals of fair play in competition, and concerns for the athlete's health.
Book ChapterDOI
CHAPTER 33 – Neurobiology of Male Sexual Behavior
TL;DR: This chapter discusses the neurobiology of male sexual behavior, which assures that mating will occur with the optimal partner at the most appropriate time and place, in order to pass parental genotypes onto the next generation.
References
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Book
The Physiology of Reproduction
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TL;DR: The gametes, fertilization and early embryogenesis the reproductive systems - the female, the male the pituitary and the hypothalmus, and the reproductive processes and their control.
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The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction
TL;DR: The IIEF addresses the relevant domains of male sexual function, is psychometrically sound, and has been linguistically validated in 10 languages and demonstrates the sensitivity and specificity for detecting treatment-related changes in patients with erectile dysfunction.
Journal ArticleDOI
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Journal ArticleDOI
Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group.
Irwin Goldstein,Tom F. Lue,Harin Padma-Nathan,Raymond C. Rosen,William D. Steers,Pierre A. Wicker +5 more
TL;DR: Oral sildenafil is an effective, well-tolerated treatment for men with erectile dysfunction and is associated with improved erectile function in the dose-response study.