Effects of troponin-I plus-C on the binding of troponin-T and its fragments to alpha-tropomyosin. Ca2+ sensitivity and cooperativity.
J R Pearlstone,L B Smillie +1 more
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TLDR
Results suggest that cooperativity exists between the two sites, presumably induced by the binding of troponin-I to tropomyosin and mediated by a conformational change in the latter.About:
This article is published in Journal of Biological Chemistry.The article was published on 1983-02-25 and is currently open access. It has received 111 citations till now. The article focuses on the topics: Tropomyosin & Cooperativity.read more
Citations
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Regulation of Contraction in Striated Muscle
TL;DR: Ca(2+) regulation of contraction in vertebrate striated muscle is exerted primarily through effects on the thin filament, which regulate strong cross-bridge binding to actin, and the physiological observations of steady-state and transient mechanical behavior are supported.
Journal ArticleDOI
Structure of the core domain of human cardiac troponin in the Ca 2+ -saturated form
TL;DR: In this article, crystal structures of the core domains (relative molecular mass of 46,000 and 52,000) of human cardiac troponin in the Ca2+-saturated form were presented.
Journal ArticleDOI
The troponin complex and regulation of muscle contraction.
TL;DR: Recent advances on a wide variety of fronts including the bacterial expression and characterization of mutants of TnC, TnI, and TnT; cross‐linking and fluorescence studies; and the determination of the crystal and nuclear magnetic resonance structures of synthetic and recombinant Troponin fragments and complexes between EF hand proteins and their target peptides have provided new insights into the nature of the interactions between troponin subunits are discussed.
Journal ArticleDOI
Vertebrate tropomyosin: distribution, properties and function.
TL;DR: In the case of muscle there is clear evidence that the TM moves its position on the F-actin filament during contraction and it is therefore considered to play an important part in the regulation of the process.
Journal ArticleDOI
Troponin T: genetics, properties and function
TL;DR: Troponin T has recently aroused clinical interest in its potential for detecting myocardial damage and the association of mutations in the cardiac isoform with hypertrophic cardiomyopathy.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Reconstitution of troponin activity from three protein components.
Marion L. Greaser,John Gergely +1 more
TL;DR: Recovery of activity could only be achieved when the required components were mixed prior to removal of urea, suggesting that one or more of these proteins may refold improperly on removal of Urea unless the other components are present.
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Comparison of amino acid sequence of troponin I from different striated muscles.
J. M. Wilkinson,Roger J.A. Grand +1 more
TL;DR: The sequence of troponin I from fast and slow skeletal and cardiac muscle shows strong homology in the region which binds to actin and is responsible for inhibition of the actomyosin ATPase.
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Structural interpretation of the two-site binding of troponin on the muscle thin filament
Alan S. Mak,Lawrence B. Smillie +1 more