Efficacy and safety of left atrial appendage closure with WATCHMAN in patients with or without contraindication to oral anticoagulation: 1-Year follow-up outcome data of the EWOLUTION trial.
Lucas V.A. Boersma,Hueseyin Ince,Stephan Kische,Evgeny Pokushalov,Thomas Schmitz,Boris Schmidt,Tommaso Gori,Felix Meincke,Alexey Vladimir Protopopov,Timothy R. Betts,David P. Foley,Horst Sievert,Patrizio Mazzone,Tom De Potter,Elisa Vireca,Kenneth M. Stein,Martin Bergmann +16 more
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TLDR
This method of stroke risk reduction appears to be safe and effective with an ischemic stroke rate as low as 1.1%, even though 73% of patients had a contraindication to and were not using oral anticoagulation.About:
This article is published in Heart Rhythm.The article was published on 2017-09-01 and is currently open access. It has received 301 citations till now. The article focuses on the topics: Stroke & Atrial fibrillation.read more
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Review on Future Targets and Current Trends in Transcatheter Left Atrial Appendage Closure
TL;DR: Three commonly used devices (Watchman, Amplatzer Cardiac Plug/Amulet, and Lariat) and their key clinical trials, special candidate patient populations, and recent investigations of the impact of post-procedure antithrombotic strategies are reviewed.
Journal ArticleDOI
Bailout left atrial appendage occluder for pulmonary vein isolation and electrical cardioversion in patients with atrial fibrillation and left atrial appendage thrombus: a pilot study
Chin Feng Tsai,Pang-Shuo Huang,Fu-Chun Chiu,Jien Jiun Chen,Shen-nan Chang,Jung-Cheng Hsu,Su Kiat Chua,Hsiao-Liang Cheng,Yi-Chih Wang,Juey-Jen Hwang,Chia Ti Tsai +10 more
TL;DR: It is demonstrated that cardioversion or CPVI is doable in symptomatic AF patients with LAA thrombus if LAA was occluded ahead as a bailout procedure, and the AF recurrence rate was similar between the two groups.
Journal ArticleDOI
Patients With Larger Left Atrial Appendage Orifice Presented Worse Prognosis Contributed by Acute Heart Failure After Left Atrial Appendage Closure
Zhongyuan Ren,Yixing Zheng,Jingying Zhang,Haotian Yang,Jiayu Wu,Hailing Li,Rong Guo,Weilun Meng,Jun Zhang,Hui-Ma Sun,Yawei Xu,Dongdong Zhao +11 more
TL;DR: A large LAA orifice could predict a post-LAAC AHF event in most patients, except for young patients, patients with paroxysmal atrial fibrillation, and/or with failed rhythm/rate control.
Journal ArticleDOI
Percutaneous Left Atrial Appendage Occlusion Therapy: Past, Present, and Future
TL;DR: Percutaneous LAA occlusion (LAAO) is increasingly being performed as an alternative to oral anticoagulants (OACs) for stroke prevention, particularly in patients with elevated bleeding risk as discussed by the authors .
Journal ArticleDOI
Evaluating Gender-based Differences in Clinical Outcomes for Patients Undergoing Left Atrial Appendage Occlusion: A Single Centre Experience.
David Hana,Tyler M. Miller,Zakeih Chaker,Muchi Ditah Chobufo,Arsalan Khan,Bansari Patel,Jonathan A. Ghobrial,Akram Kawsara,Jesse Thompson,Bryan Raybuck,Vinay Badhwar,Ramesh Daggubatti,James D. Mills,Yasmin S. Hamirani +13 more
TL;DR: In this article , the authors found that women were more prone to major adverse events after trans catheter left atrial appendage occlusion compared with men. But no statistically significant differences were noted between both genders regarding the follow-up outcome.
References
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Paulus Kirchhof,Stefano Benussi,Dipak Kotecha,Anders Ahlsson,Dan Atar,Barbara Casadei,Manuel Castellá,Hans-Christoph Diener,Hein Heidbuchel,Jeroen M.L. Hendriks,Gerhard Hindricks,Antonis S. Manolis,Jonas Oldgren,Bogdan A. Popescu,Ulrich Schotten,Bart P. Van Putte,Panagiotis Vardas,Stefan Agewall,John Camm,Gonzalo Barón Esquivias,Werner Budts,Scipione Carerj,Filip Casselman,Antonio Coca,Raffaele De Caterina,Spiridon Deftereos,Dobromir Dobrev,José M. Ferro,Gerasimos Filippatos,Donna Fitzsimons,Bulent Gorenek,Maxine Guenoun,Stefan H. Hohnloser,Philippe Kolh,Gregory Y.H. Lip,Athanasios J. Manolis,John J.V. McMurray,Piotr Ponikowski,Raphael Rosenhek,Frank Ruschitzka,Irina Savelieva,Sanjay Sharma,Piotr Suwalski,Juan Tamargo,Clare J Taylor,Isabelle C. Van Gelder,Adriaan A. Voors,Stephan Windecker,José Luis Zamorano,Katja Zeppenfeld +49 more
TL;DR: The Task Force for the management of atrial fibrillation of the European Society of Cardiology has been endorsed by the European Stroke Organisation (ESO).
Journal ArticleDOI
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS: The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC). Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Endorsed by the European Stroke Organisation (ESO)
Journal ArticleDOI
Standardized Bleeding Definitions for Cardiovascular Clinical Trials A Consensus Report From the Bleeding Academic Research Consortium
Roxana Mehran,Sunil V. Rao,Deepak L. Bhatt,C. Michael Gibson,Adriano Caixeta,John W. Eikelboom,Sanjay Kaul,Stephen D. Wiviott,Venu Menon,Eugenia Nikolsky,Victor L. Serebruany,Marco Valgimigli,Pascal Vranckx,David P. Taggart,Joseph F. Sabik,Donald E. Cutlip,Mitchell W. Krucoff,E. Magnus Ohman,Philippe Gabriel Steg,Harvey D. White +19 more
TL;DR: Bleeding complications have been associated with an increased risk of subsequent adverse outcomes, including MI, stroke, stent thrombosis, and death, in patients with ACS and in those undergoing percutaneous coronary intervention (PCI) as well as in the long-term antithrombotic setting.
Journal ArticleDOI
Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation
TL;DR: Data suggest that left atrial appendage obliteration is a strategy of potential value for stroke prophylaxis in nonrheumatic atrial fibrillation.
Journal ArticleDOI
Prospective Randomized Evaluation of the Watchman Left Atrial Appendage Closure Device in Patients With Atrial Fibrillation Versus Long-Term Warfarin Therapy: The PREVAIL Trial
David R. Holmes,Saibal Kar,Matthew J. Price,Brian Whisenant,Horst Sievert,Shephal K. Doshi,Kenneth C. Huber,Vivek Y. Reddy +7 more
TL;DR: In this trial, LAA occlusion was noninferior to warfarin for ischemic stroke prevention or SE >7 days' post-procedure in patients with NVAF who do not have an absolute contraindication to short-termwarfarin therapy.
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Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation
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