Efficacy and safety of left atrial appendage closure with WATCHMAN in patients with or without contraindication to oral anticoagulation: 1-Year follow-up outcome data of the EWOLUTION trial.
Lucas V.A. Boersma,Hueseyin Ince,Stephan Kische,Evgeny Pokushalov,Thomas Schmitz,Boris Schmidt,Tommaso Gori,Felix Meincke,Alexey Vladimir Protopopov,Timothy R. Betts,David P. Foley,Horst Sievert,Patrizio Mazzone,Tom De Potter,Elisa Vireca,Kenneth M. Stein,Martin Bergmann +16 more
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TLDR
This method of stroke risk reduction appears to be safe and effective with an ischemic stroke rate as low as 1.1%, even though 73% of patients had a contraindication to and were not using oral anticoagulation.About:
This article is published in Heart Rhythm.The article was published on 2017-09-01 and is currently open access. It has received 301 citations till now. The article focuses on the topics: Stroke & Atrial fibrillation.read more
Citations
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Journal ArticleDOI
Comparison of fluoroscopy and transesophageal echocardiogram for intra-procedure device surveillance assessment during implantation of Watchman.
Xiaochun Zhang,Qinchun Jin,Dehong Kong,Yingying Jiang,Shasha Chen,Dandan Chen,Cody R. Hou,Lei Zhang,Cuizhen Pan,Daxin Zhou,Junbo Ge +10 more
TL;DR: It is suggested that this minimalist approach to LAAO performed by experienced operators in large volume centers is feasible under fluoroscopy guidance and could be proposed in cases with contraindication to general anesthesia and/or TEE.
Journal ArticleDOI
Optimal combination strategy of left atrial appendage closure plus catheter ablation in a single procedure in patients with nonvalvular atrial fibrillation.
Xianfeng Du,Huimin Chu,Bin He,Binhao Wang,Jing Liu,Mingjun Feng,Yibo Yu,Guohua Fu,He Jin,Fang Gao,Jingjing Zhu,Xiaomin Chen +11 more
TL;DR: The efficacy and safety of combining left atrial appendage closure (LAAC) plus atrial fibrillation (AF) catheter ablation in a single procedure has been established, but the optimal combination strategy has not been thoroughly elucidated to date.
Journal ArticleDOI
Preclinical assessment of a modified Occlutech left atrial appendage closure device in a porcine model.
Markus Reinthaler,Johannes Grosshauser,Tanja Schmidt,Juliane K. Unger,Ross Morgan,Friederike Zimmermann,Johannes Jakob Hartung,C Seppelt,D Meteva,Wolfram Haider,Ulf Landmesser,Carsten Skurk +11 more
TL;DR: In this paper, a modified occlutech LAA closure device was implanted in 12 female pigs under fluoroscopic and transesophageal echocardiography (TEE) guidance and evaluated peri-procedurally and after 4, 8, and 12 weeks.
Journal ArticleDOI
Left atrial appendage occlusion in atrial fibrillation patients with previous intracranial bleeding: A national multicenter study
Gavino Casu,Giuseppe D'Angelo,Fabrizio Ugo,Federico Ronco,Federico Simonetto,Marco Barbierato,Valeria Magni,Giacomo Boccuzzi,Alberto Margonato,Francesco Moroni,Alessandro P Delitala,Giovanni Lorenzoni,Alessandro Beneduce,Francesco Rametta,Patrizio Mazzone,Paolo Della Bella,Matteo Montorfano,Pierluigi Merella +17 more
TL;DR: Percutaneous LAA occlusion is an effective option for AF patients and previous intracranial hemorrhage and a single antiplatelet therapy strategy could be considered for patients with the highest risk of recurrent bleeding.
Journal ArticleDOI
The Impact of CHA2DS2-VASc and HAS-BLED Scores on Clinical Outcomes in the Amplatzer Amulet Study.
Giuseppe Tarantini,Gianpiero D'Amico,Boris Schmidt,Patrizio Mazzone,Sergio Berti,Sven Fischer,Juha Lund,Matteo Montorfano,Paolo Della Bella,Simon Cheung Chi Lam,Ignacio Cruz-González,Ryan Gage,Hong Zhao,Heyder Omran,Jacob Odenstedt,Jens Erik Nielsen-Kudsk +15 more
TL;DR: LAAO with the Amplatzer Amulet reduced the risk of ischemic stroke compared with the predicted rate, with a greater magnitude among patients at high thromboembolic risk without increasing the bleeding risk.
References
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Journal ArticleDOI
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Paulus Kirchhof,Stefano Benussi,Dipak Kotecha,Anders Ahlsson,Dan Atar,Barbara Casadei,Manuel Castellá,Hans-Christoph Diener,Hein Heidbuchel,Jeroen M.L. Hendriks,Gerhard Hindricks,Antonis S. Manolis,Jonas Oldgren,Bogdan A. Popescu,Ulrich Schotten,Bart P. Van Putte,Panagiotis Vardas,Stefan Agewall,John Camm,Gonzalo Barón Esquivias,Werner Budts,Scipione Carerj,Filip Casselman,Antonio Coca,Raffaele De Caterina,Spiridon Deftereos,Dobromir Dobrev,José M. Ferro,Gerasimos Filippatos,Donna Fitzsimons,Bulent Gorenek,Maxine Guenoun,Stefan H. Hohnloser,Philippe Kolh,Gregory Y.H. Lip,Athanasios J. Manolis,John J.V. McMurray,Piotr Ponikowski,Raphael Rosenhek,Frank Ruschitzka,Irina Savelieva,Sanjay Sharma,Piotr Suwalski,Juan Tamargo,Clare J Taylor,Isabelle C. Van Gelder,Adriaan A. Voors,Stephan Windecker,José Luis Zamorano,Katja Zeppenfeld +49 more
TL;DR: The Task Force for the management of atrial fibrillation of the European Society of Cardiology has been endorsed by the European Stroke Organisation (ESO).
Journal ArticleDOI
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS: The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC). Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Endorsed by the European Stroke Organisation (ESO)
Journal ArticleDOI
Standardized Bleeding Definitions for Cardiovascular Clinical Trials A Consensus Report From the Bleeding Academic Research Consortium
Roxana Mehran,Sunil V. Rao,Deepak L. Bhatt,C. Michael Gibson,Adriano Caixeta,John W. Eikelboom,Sanjay Kaul,Stephen D. Wiviott,Venu Menon,Eugenia Nikolsky,Victor L. Serebruany,Marco Valgimigli,Pascal Vranckx,David P. Taggart,Joseph F. Sabik,Donald E. Cutlip,Mitchell W. Krucoff,E. Magnus Ohman,Philippe Gabriel Steg,Harvey D. White +19 more
TL;DR: Bleeding complications have been associated with an increased risk of subsequent adverse outcomes, including MI, stroke, stent thrombosis, and death, in patients with ACS and in those undergoing percutaneous coronary intervention (PCI) as well as in the long-term antithrombotic setting.
Journal ArticleDOI
Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation
TL;DR: Data suggest that left atrial appendage obliteration is a strategy of potential value for stroke prophylaxis in nonrheumatic atrial fibrillation.
Journal ArticleDOI
Prospective Randomized Evaluation of the Watchman Left Atrial Appendage Closure Device in Patients With Atrial Fibrillation Versus Long-Term Warfarin Therapy: The PREVAIL Trial
David R. Holmes,Saibal Kar,Matthew J. Price,Brian Whisenant,Horst Sievert,Shephal K. Doshi,Kenneth C. Huber,Vivek Y. Reddy +7 more
TL;DR: In this trial, LAA occlusion was noninferior to warfarin for ischemic stroke prevention or SE >7 days' post-procedure in patients with NVAF who do not have an absolute contraindication to short-termwarfarin therapy.
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