Journal ArticleDOI
Efficient access to 1,4-benzothiazine: palladium-catalyzed double C-S bond formation using Na2S2O3 as sulfurating reagent.
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TLDR
A novel Pd-catalyzed double C-S bond formation coupling reaction has been developed that provides an efficient method for the synthesis of substituted 1,4-benzothiazine derivates, which are structural elements of numerous bioactivity molecules rendering this protocol attractive to both synthetic and medicinal chemistry.About:
This article is published in Organic Letters.The article was published on 2013-05-09. It has received 165 citations till now. The article focuses on the topics: Reagent & Benzothiazine.read more
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Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry
TL;DR: Sulfonamides, thioethers, sulfones and Penicillin are the most common scaffolds in sulfur containing drugs, which are well studied both on synthesis and application during the past decades.
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Transfer of sulfur: from simple to diverse.
Hui Liu,Xuefeng Jiang +1 more
TL;DR: This Focus Review collects and summarize the C-S bond-formation reactions that have been used to construct C- S bonds in natural products and pharmaceutical compounds.
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Transition-metal-catalyzed C-S bond coupling reaction.
TL;DR: Recent efforts in metal-catalyzed C-S bond cross-coupling reactions are summarized, focusing especially on the coupling of thiols with aryl- and vinyl halides based on different metals.
Pd-Catalyzed Synthesis of Ar-SCF3 Compounds under Mild Conditions
TL;DR: This work hypothesized that a similar Pd-based system might allow for the formation of an aromatic C–SCF3 bond after the successful coupling of weak nucleophiles traditionally thought to be reluctant participants in the transmetalation or reductive elimination steps of a typical Pd(0)/Pd(II) catalytic cycle.
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Late stage trifluoromethylthiolation strategies for organic compounds.
TL;DR: Addition reactions of electrophilic reagents to double and triple bonds followed by ring-cyclizations will be shown to yield relevant CF3S-substituted heteroaromatic compounds with relevant pharmacological action.
References
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A general and long-lived catalyst for the palladium-catalyzed coupling of aryl halides with thiols.
TL;DR: A general catalytic system for the coupling of aryl halides and sulfonates with thiols based on the use of the CyPF-t-Bu ligand and the synthesis of a diarylsulfide from two bromoarenes was accomplished using a hydrogen sulfide surrogate.
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Iron-Catalyzed S-Arylation of Thiols with Aryl Iodides
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A General Palladium-Catalyzed Coupling of Aryl Bromides/Triflates and Thiols
Takahiro Itoh,Toshiaki Mase +1 more
TL;DR: An efficient palladium-catalyzed carbon-sulfur bond formation reaction of aryl bromides, triflates, and activated aryL chloride is developed that has shown tolerance to a wide variety of aries and alkyl thiols that can also be used as sulfide equivalents.
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Cobalt-Catalyzed Aryl−Sulfur Bond Formation
TL;DR: A new cobalt-catalyzed coupling of aryl halides with thiophenols and alkanethiols is reported, which represents an interesting addition to previously known methods to synthesize thioethers.
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A general and efficient method for the palladium-catalyzed cross-coupling of thiols and secondary phosphines
Miki Murata,Stephen L. Buchwald +1 more
TL;DR: In this paper, a broad substrate scope of aryl bromides and chlorides can be coupled to aliphatic and aromatic thiols using Pd(OAc)2/1, 1,1,1′-bis(diisopropylphosphino)ferrocene as the catalyst.