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Electrochemical Selenylative Carbannulation of Biaryl Ynones to Seleno-Dibenzocycloheptenones/Spiro[5.5]Trienones.

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TLDR
In this article, a method for the synthesis of structurally diverse seleno-dibenzocyclohepten-5-ones and selenon-spiro[5.5]trienones by selenylative carbannulation of biaryl ynones with diary l diselenide was developed.
Abstract
Electrooxidative-induced synthesis of structurally diverse seleno-dibenzocyclohepten-5-ones and seleno-spiro[5.5]trienones by selenylative carbannulation of biaryl ynones with diaryl diselenide has been developed. The switchable reactivity, intramolecular ortho-annulation or dearomative ipso-annulation, is directed by the substituent present on the ortho-aryl group of aryl-ynone. The prominent features of this method include metal-free, external chemical oxidant-free conditions, and readily accessible substrates.

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K2S2O8/I2-Promoted Electrophilic Selenylative Cyclization To Access Seleno-Benzo[b]azepines.

TL;DR: A novel and simple organoselenium-involved 7-membered cyclization to access diverse seleno-benzo[b]azepines and large-scale experiment reveal the promising utility of this methodology.
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Synthesis of Seleno-Dibenzocycloheptenones/Spiro[5.5]Trienones by Radical Cyclization of Biaryl Ynones.

TL;DR: In this paper , an alternative method for the synthesis of seleno-dibenzocycloheptenones and selenon-spiro[5.5]trienones through the radical cyclization of biaryl ynones, using Oxone as a green oxidizing agent.
Journal ArticleDOI

Iron‐Catalyzed Silylation and Spirocyclization of Biaryl‐Ynones: A Radical Cascade Process toward Silylated Spiro[5.5]trienones

TL;DR: In this paper , an iron-catalyzed cascade silyl radical addition/6-exo-trig cyclization/dearomatization of biaryl ynones has been developed.
Journal ArticleDOI

Regio- and stereo-selective electrochemical selenoalkylation of alkynes with 1,3-dicarbonyl compounds and diselenides

TL;DR: In this article , a regio-and stereo-selective electrochemical approach for the seleno(monofluoro)alkylation of alkynes with 1,3-dicarbonyl compounds and diselenides has been developed.
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Electrochemical electrophilic bromination/spirocyclization of <i>N</i>-benzyl-acrylamides to brominated 2-azaspiro[4.5]decanes

TL;DR: In this paper , an electrochemical electrophilic bromination/spirocyclization of N -benzyl-acrylamides to brominated 2-azaspiro[4.5]decanes with 2-bromoethan-1-ol as the brominating reagent has been developed.
References
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Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance

TL;DR: This review discusses advances in synthetic organic electrochemistry since 2000 with enabling methods and synthetic applications analyzed alongside innate advantages as well as future challenges of electroorganic chemistry.
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Organoselenium and Organotellurium Compounds: Toxicology and Pharmacology

TL;DR: The development of new organochalcogens with higher thiol-peroxidase activity that can use other non-toxic thiol reducing agents, such as N-acetylcysteine instead of glutathione, will permit the investigation of the co-administration of organochAlcogens and thiols as a formulation for antioxidant therapy.
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Electrifying Organic Synthesis

TL;DR: This Review surveys recent developments in electrochemical synthesis that will influence the future of this area and examines the role of stoichiometric reagents in this area.
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The use of spirocyclic scaffolds in drug discovery

TL;DR: A brief review of selected examples from the primary medicinal chemistry literature during the last three years to demonstrate the versatility of spiro scaffolds.
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Electrochemical Oxidative Cross-coupling with Hydrogen Evolution: A Green and Sustainable Way for Bond Formation

TL;DR: In this paper, an overview of the recent developments in this emerging field can be found, along with a review of some of the most relevant works. But, the authors do not discuss the role of an appropriate sacrificial oxidant.