Electroencephalographic source imaging: a prospective study of 152 operated epileptic patients
Verena Brodbeck,Laurent Spinelli,Agustina M. Lascano,Michael Wissmeier,Maria Vargas,Serge Vulliemoz,Claudio Pollo,Karl Lothard Schaller,Christoph M. Michel,Margitta Seeck +9 more
TLDR
It is concluded that electric source imaging is a highly valuable tool in pre-surgical epilepsy evaluation given the low cost and high flexibility of electroencephalographic systems even with high channel counts.Abstract:
Electroencephalography is mandatory to determine the epilepsy syndrome. However, for the precise localization of the irritative zone in patients with focal epilepsy, costly and sometimes cumbersome imaging techniques are used. Recent small studies using electric source imaging suggest that electroencephalography itself could be used to localize the focus. However, a large prospective validation study is missing. This study presents a cohort of 152 operated patients where electric source imaging was applied as part of the pre-surgical work-up allowing a comparison with the results from other methods. Patients (n = 152) with >1 year postoperative follow-up were studied prospectively. The sensitivity and specificity of each imaging method was defined by comparing the localization of the source maximum with the resected zone and surgical outcome. Electric source imaging had a sensitivity of 84% and a specificity of 88% if the electroencephalogram was recorded with a large number of electrodes (128-256 channels) and the individual magnetic resonance image was used as head model. These values compared favourably with those of structural magnetic resonance imaging (76% sensitivity, 53% specificity), positron emission tomography (69% sensitivity, 44% specificity) and ictal/interictal single-photon emission-computed tomography (58% sensitivity, 47% specificity). The sensitivity and specificity of electric source imaging decreased to 57% and 59%, respectively, with low number of electrodes (<32 channels) and a template head model. This study demonstrated the validity and clinical utility of electric source imaging in a large prospective study. Given the low cost and high flexibility of electroencephalographic systems even with high channel counts, we conclude that electric source imaging is a highly valuable tool in pre-surgical epilepsy evaluation.read more
Citations
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Epilepsy: new advances
TL;DR: The lives of most people with epilepsy continue to be adversely affected by gaps in knowledge, diagnosis, treatment, advocacy, education, legislation, and research and Concerted actions to address these challenges are urgently needed.
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Towards the utilization of EEG as a brain imaging tool
TL;DR: It is shown that many cognitive and clinical EEG studies use the EEG still in its traditional way and analyze grapho-elements at certain electrodes and latencies, which is not only dangerous because it leads to misinterpretations, but it is also largely ignoring the spatial aspects of the signals.
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EEG Source Imaging: A Practical Review of the Analysis Steps.
Christoph M. Michel,Denis Brunet +1 more
TL;DR: This review explains several steps needed to pass from the recording of the EEG to 3-dimensional images of neuronal activity and illustrates them in a comprehensive analysis pipeline integrated in a stand-alone freely available academic software: Cartool.
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Epilepsy surgery in children and adults
Philippe Ryvlin,Philippe Ryvlin,Philippe Ryvlin,J. Helen Cross,Sylvain Rheims,Sylvain Rheims +5 more
TL;DR: New guidelines recommend earlier and more systematic assessment of patients' eligibility for surgery than is seen at present, as evidence is scarce for the indication and effect of most presurgical investigations, with no biomarker precisely delineating the epileptogenic zone.
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Very high density EEG elucidates spatiotemporal aspects of early visual processing
Amanda K. Robinson,Praveen Venkatesh,Matthew J. Boring,Matthew J. Boring,Michael J. Tarr,Pulkit Grover,Marlene Behrmann +6 more
TL;DR: “super-Nyquist” density EEG (“SND”) with Nyquist density arrays for assessing the spatiotemporal aspects of early visual processing argued for increased development of this approach in basic and translational neuroscience.
References
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EEG source imaging
Christoph M. Michel,Micah M. Murray,Göran Lantz,Sara L. Gonzalez,Laurent Spinelli,Rolando Grave de Peralta +5 more
TL;DR: It is shown that modern EEG source imaging simultaneously details the temporal and spatial dimensions of brain activity, making it an important and affordable tool to study the properties of cerebral, neural networks in cognitive and clinical neurosciences.
Journal ArticleDOI
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