Journal ArticleDOI
Emerging Technologies: Systems Biology
TLDR
During the 232nd National Meeting of the American Chemical Society, a session devoted to the emerging technology of Systems Biology was held, with a common theme of using a systems biology approach to aid in the understanding of fundamental biology, with an eye toward applications for the benefit of society.Abstract:
The field of systems biology is based on the paradigm that the whole is greater than the sum of the parts. Through a combination of high-throughput experiments analyzing “-omic” scale phenomenon and the development of new computational techniques and algorithms, it is now feasible to study biological systems in a way that was previously not possible. During the 232nd National Meeting of the American Chemical Society, a session devoted to the emerging technology of Systems Biology was held. A number of talks on a wide variety of subjects covering cell signaling, network regulation and analysis, novel experimental procedures, synthetic biology, and metabolic flux analysis were presented. All of these approaches shared the common theme of using a systems biology approach to aid in the understanding of fundamental biology, with an eye toward applications for the benefit of society.read more
Citations
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Journal ArticleDOI
Dynamic combinatorial/covalent chemistry: a tool to read, generate and modulate the bioactivity of compounds and compound mixtures
TL;DR: A conceptual overview of how the impact of DCC on supramolecular assemblies at different levels can allow us to understand, predict and modulate the complexity of biological systems is given.
Journal ArticleDOI
Building the developmental oculome: systems biology in vertebrate eye development and disease.
Salil A. Lachke,Richard L. Maas +1 more
TL;DR: The present understanding of two of the individual components of the developing vertebrate eye—the lens and retina—at both the molecular and systems levels are discussed, and the directions and tools required for construction of the developmental oculome are outlined.
Journal ArticleDOI
Transcriptome Analysis of Dairy Goat Mammary Gland Tissues from Different Lactation Stages.
Zhibin Ji,Tianle Chao,Chunlan Zhang,Zhaohua Liu,Lei Hou,Jin Wang,Aili Wang,Yong Wang,Jie Zhou,Rong Xuan,Guizhi Wang,Jianmin Wang +11 more
TL;DR: High-throughput sequencing technology and bioinformatics methods systematically analyze the transcriptome of Laoshan dairy goat mammary gland tissues from different lactation stages to support the involvement of the constructed network in the regulation of mammary glands development and lactation and increase the in-depth understanding of the lactation physiology of dairy goats.
Dissertation
Knowledge derivation and data mining strategies for probabilistic functional integrated networks
TL;DR: One of the most powerful integration techniques, probabilistic functional integrated networks (PFINs), is extended to incorporate a concept of biological relevance, which significantly reduces the hypothesis space for experimental validation of genes hypothesised to be involved in the oxidative stress response.
Journal ArticleDOI
Contributions and perspectives of chicken genomics in Brazil: from biological model to export commodity
Erika Cristina Jorge,Antonio Figueira,Mônica Corrêa Ledur,Ana Silvia Alves Meira Tavares Moura,Luiz Lehmann Coutinho +4 more
TL;DR: Recent developments in poultry genomics and their contribution to adding functional information to the already existing structural genomics are reviewed, including the availability of the complete genome sequence, a comprehensive collection of mRNA sequences, microarray platforms, and their use to complement QTL mapping strategies in the identification of genes that underlie complex traits.
References
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Book
Metabolic Engineering: Principles and Methodologies
TL;DR: The Essence of Metabolic Engineering, a review of Cellular Metabolism, and Examples of Pathway Manipulations: Metabolic engineering in Practice are reviewed.
Journal ArticleDOI
In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data
TL;DR: This study demonstrates how the combination of in silico and experimental biology can be used to obtain a quantitative genotype–phenotype relationship for metabolism in bacterial cells.
Journal ArticleDOI
Bacteria–host communication: The language of hormones
Vanessa Sperandio,Alfredo G. Torres,Alfredo G. Torres,Bruce B. Jarvis,James P. Nataro,James B. Kaper +5 more
TL;DR: It is shown that an EHEC luxS mutant, unable to produce the bacterial autoinducer, still responds to a eukaryotic cell signal to activate expression of its virulence genes, implying a potential cross-communication between the luxS/AI-3 bacterial QS system and the epinephrine host signaling system.
Journal ArticleDOI
Multiple signalling systems controlling expression of luminescence in Vibrio harveyi: sequence and function of genes encoding a second sensory pathway.
TL;DR: Analysis of signalling mutant phenotypes indicates that there are at least two separate signal‐response pathways which converge to regulate expression of luminescence in V. harveyl.
MAKING 'SENSE' OF METABOLISM: AUTOINDUCER2, LuxS AND PATHOGENIC BACTERIA
TL;DR: The influence that LuxS and its product, autoinducer-2, have on virulence is discussed, relating the current evidence to the preferred niche of the pathogen and the underlying mechanisms involved.