Journal ArticleDOI
Endocytosis via galactose receptors in vivo. Ligand size directs uptake by hepatocytes and/or liver macrophages.
Jutta Schlepper-Schäfer,Dorothea Hülsmann,Assadollah Djovkar,Helmut E. Meyer,Lothar Herbertz,Hubert Kolb,Victoria Kolb-Bachofen +6 more
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TLDR
In vivo uptake by liver macrophages is mediated by galactose-specific recognition as shown by inhibition with GalNAc, while N-acetylglucosamine (GlcNAc) is without effect and GlNAc showed no inhibitory effect.About:
This article is published in Experimental Cell Research.The article was published on 1986-08-01. It has received 81 citations till now. The article focuses on the topics: Hepatocyte & Ligand (biochemistry).read more
Citations
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Journal ArticleDOI
Local control of the immune response in the liver.
Percy A. Knolle,G. Gerken +1 more
TL;DR: Experimental data are summarized that shed light on the molecular mechanisms and the cell populations of the liver involved in local immune regulation in the liver that contribute to tolerance induction by deletion of T cells through induction of apoptosis.
Journal ArticleDOI
Living in the liver: hepatic infections
TL;DR: The interplay between pathogens and host factors that promote pathogen elimination and maintain organ integrity or that allow pathogen persistence are described.
Journal ArticleDOI
Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR
Stefan Pöhlmann,Jie Zhang,Frédéric Baribaud,Zhiwei Chen,George J. Leslie,George Lin,Angela Granelli-Piperno,Robert W. Doms,Charles M. Rice,Jane A. McKeating +9 more
TL;DR: It is found that soluble versions of the hepatitis C virus (HCV) E2 glycoprotein and retrovirus pseudotypes expressing chimeric forms of both HCV E1 and E1 glycoproteins bound efficiently toDC-SIGN and DC-SIGNR expressed on cell lines and primary human endothelial cells but not to other C-type lectins tested.
Journal ArticleDOI
Hepatic Drug Targeting: Phase I Evaluation of Polymer-Bound Doxorubicin
Leonard W. Seymour,D. R. Ferry,David E. Anderson,Stuart Hesslewood,Peter J. Julyan,Richard Poyner,J. Doran,Annie M. Young,Sally Burtles,David J. Kerr +9 more
TL;DR: Liver-specific doxorubicin delivery is achievable using galactosamine-modified polymers, and targeting is also seen in primary hepatocellular tumors, and the recommended PK2 dose is 120 mg/m(2), administered every 3 weeks by IV infusion.
Patent
Stable lipid-comprising drug delivery complexes and methods for their production
TL;DR: In this article, a stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described and the biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method.
References
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Journal ArticleDOI
A low-viscosity epoxy resin embedding medium for electron microscopy.
TL;DR: A low-viscosity embedding medium based on ERL-4206 is recommended for use in electron microscopy and has a long pot life of several days and infiltrates readily because of its low viscosity.
Journal ArticleDOI
Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions
TL;DR: In this article, a series of monodisperse suspensions of the same chemical composition but of rather different particle sizes was used to study particle size dependent phenomena, such as Brownian motion, light scattering, sedimentation and electrophoresis of small particles.
Journal ArticleDOI
Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study.
TL;DR: The extent to which nonhepatocytic organelles can potentially contaminate subcellular fractions used for biochemical studies is demonstrated, particularly important for the interpretation of studies on lysosomes, plasma membrane, and Golgi apparatus.
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