Journal ArticleDOI
Environmental monitoring of urban streams using a primary fish gill cell culture system (FIGCS)
Sabine Schnell,K. A. Bawa-Allah,Adebayo A. Otitoloju,Christer Hogstrand,Thomas H. Miller,Leon Barron,Nic Bury +6 more
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TLDR
The primary fish gill cell culture system (FIGCS) is an in vitro technique which has the potential to replace animals in whole effluent toxicity tests and the increase in the expression of genes encoding mta, cyp1a1 and cyp3a27 in FIGCS is indicative of the presence of biologically active pollutants.About:
This article is published in Ecotoxicology and Environmental Safety.The article was published on 2015-10-01. It has received 19 citations till now.read more
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Uptake of propranolol on ionic liquid iron nanocomposite adsorbent: Kinetic, thermodynamics and mechanism of adsorption
TL;DR: In this article, an ionic liquid iron nano-composite adsorbent was used for removing propranolol drug residue from water using a green technology, analyzed and exploited as sorbent for removal of drug residue in water.
Journal ArticleDOI
Occurrence of caffeine in the freshwater environment: Implications for ecopharmacovigilance.
TL;DR: A worldwide analysis of 132 reports of caffeine residues in freshwater environments indicated that more than 70% of the studies reported were from Asia and Europe, which have densely populated and industrially developed areas, however, caffeine pollution was also found to affect areas isolated from human influence, such as Antarctica.
Journal ArticleDOI
Procedures for the reconstruction, primary culture and experimental use of rainbow trout gill epithelia.
Sabine Schnell,Lucy C Stott,Christer Hogstrand,Chris M. Wood,Scott P. Kelly,Peter Pärt,Stewart F. Owen,Nicolas R. Bury +7 more
TL;DR: The double-seeded insert technique can be used to study freshwater gill physiology, and it is a humane alternative for toxicity testing, bioaccumulation studies and environmental water quality monitoring.
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Applicability of in vitro methods in evaluating the biotransformation of polycyclic aromatic hydrocarbons (PAHs) in fish: Advances and challenges.
Marco E. Franco,Ramon Lavado +1 more
TL;DR: The present review provides up-to-date information on the use of in vitro fish models in the evaluation of PAH biotransformation, common biomarkers, and challenges encountered when developing and applying such systems.
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Toxicokinetic and toxicodynamic (TK-TD) modeling to study oxidative stress-dependent toxicity of heavy metals in zebrafish.
TL;DR: It is suggested that the TK-TD model based on ROS and MDA could be used as a quantitative AOP to predict toxicity of metals to zebrafish.
References
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Journal ArticleDOI
In vitro: Response of plant growth regulators and antimalformins on conidia germination of Fusarium mangiferae and incidence of mango malformation
TL;DR: The present findings do not authenticate the involvement of F. mangiferae in the disease, however hormonal imbalance, most probably ethylene, might be responsible for deformed functional morphology of panicle and a signal transduction mechanism of stress-stimulated ethylene imbalance causing physio-morphological changes in reproductive organs of mango flower and thereby failure of fertilization and fruit set needs to be investigated.
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CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.
Gang Luo,Mark R. Cunningham,Sean Kim,Tim Burn,Jianrong Lin,Michael Sinz,Geraldine A. Hamilton,Christopher Rizzo,Summer Jolley,Darryl Gilbert,April Downey,Daniel R. Mudra,Richard A. Graham,Kathy Carroll,Jindong Xie,Ajay Madan,Andrew Parkinson,Dave Christ,Bernard H. Selling,Edward L. LeCluyse,Liang-Shang Gan +20 more
TL;DR: It is concluded that the PXR reporter gene assay is a reliable and complementary method to assess the CYP3A4 induction potential of drugs and other xenobiotics.
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Effects of human pharmaceuticals on cytotoxicity, EROD activity and ROS production in fish hepatocytes.
TL;DR: Compared to hepatocytes from human and dog, fish hepatocytes seemed to be more susceptible to the peroxisome proliferators (PPs) CF and FF, which may be of concern at the biological and chemical levels in a multipollution context.
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The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish.
Sonya M. Billiard,Alicia R. Timme-Laragy,Deena Wassenberg,Crystal J. Cockman,Richard T. Di Giulio +4 more
TL;DR: It is demonstrated here that coexposure of zebrafish embryos to the PAH-type AHR agonist beta-naphthoflavone (BNF) and the CYP1A inhibitor alpha- naphth oflav one (ANF) significantly enhanced toxicity above that observed for single-compound exposures, and suggested that mechanisms underlying developmental toxicity of PAH -type A HR agonists are different from those of pHAHs.
Journal ArticleDOI
Cytochrome P450 (CYP) in fish.
TL;DR: An overview of the CYP families in fish is presented, focusing on eight families that have been studied in detail and provided insights into the regulation of P450 genes by environmental stresses including water pollution.