Enzymatic reduction of folic acid and dihydrofolic acid to tetrahydrofolic acid
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TLDR
Studies now indicate that FA and FAH:! are reduced to FAHJ with reduced pyridine nucleotides in the presence of an enzyme system partially purified from chicken liver.About:
This article is published in Journal of Biological Chemistry.The article was published on 1957-10-01 and is currently open access. It has received 398 citations till now. The article focuses on the topics: Dihydrofolic acid & Tetrahydrofolic acid.read more
Citations
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Analysis of reduced forms of biopterin in biological tissues and fluids.
Takeshi Fukushima,Jon C. Nixon +1 more
TL;DR: A reverse-phese high-performance liquid chromatography procedure was developed for the separation of biopterin from other unconjugated pteridines and a possible role for tetrahydroneopterin as a cofactor in the enzymatic hydroxylation of aromatic amino acids in man is discussed.
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Crystalline Dihydropteroylglutamic Acid
TL;DR: By reducing purified pteroylglutamate with sodium dithionite according to the method of Futterman and twice precipitating the product by slow adjustment of the pH, it has now been found possible to obtain dihydropteroy lglutamic acid consistently as a white crystalline product giving analytical results agreeing fairly well with the theoretical values.
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Specific Binding of 4-Amino Folic Acid Analogues by Folic Acid Reductase
TL;DR: Experiments are described which demonstrate that the agent which binds amethopterin and related 4-amino derivatives of folic Acid is the enzyme folic acid reductase and that this binding is specific and exceedingly tight.
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Studies on the mechanism of the enzymatic conversion of phenylalanine to tyrosine.
Journal ArticleDOI
Phenylketonuria Due to a Deficiency of Dihydropteridine Reductase
TL;DR: Assessment of reductase in cultured skin fibroblasts may be advisable in the initial diagnosis of phenylketonuria on the basis of results of assays of components of the phenylalanine hydroxylating system.
References
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