Epidemiologic and Clinical Characteristics of Monkeypox Cases — United States, May 17–July 22, 2022
David H. Philpott,Christine M. Hughes,Karen A. Alroy,Janna L. Kerins,Jessica Pavlick,Lenore Asbel,Addie Crawley,Alexandra P. Newman,Hillary Spencer,Amanda Feldpausch,Kelly E. Cogswell,K. R. Davis,Jinlene Chen,Tiffany Henderson,Katherine R. Murphy,Meghan Barnes,Brandi Hopkins,Mary-Margaret A. Fill,Anil T. Mangla,Dana Perella,Arti Barnes,Scott Hughes,Jayne Griffith,Abby L. Berns,Lauren Milroy,Haley Blake,Maria M. Sievers,Melissa Marzan-Rodriguez,Marco E. Tori,Stephanie R. Black,Erik J. Kopping,Irene Ruberto,Angela M Maxted,Anuj Sharma,Kara D Tarter,Sydney A. Jones,Brooklynn R. White,Ryan Chatelain,M. Russo,Sarah Gillani,Ethan Bornstein,Stephen White,SA Johnson,Emma Ortega,Lori Saathoff-Huber,Anam Syed,Aprielle B. Wills,Bridget J. Anderson,Alexandra M. Oster,Athalia Christie,Jennifer H. McQuiston,Andrea M. McCollum,Agam K Rao,M. Negron,Isabel Griffin,Mohammed Iqbal Khan,Yasmin P Ogale,Emily Sims,R. Ryan Lash,Jeanette J. Rainey,Kelly Charniga,Michelle A Waltenburg,Patrick Dawson,Laura A S Quilter,Julie Rushmore,Mark Stenger,Rachel Kachur,Florence Whitehill,Kelly A. Jackson,James J. Collins,Kimberly Signs,Gillian Richardson,Julie Hand,Emily Spence-Davizon,Brandi L. Steidley,Matthew Osborne,Susan Soliva,S. S. Cook,Leslie Ayuk-Takor,Christina Willut,Alexandria Snively,Nicholas Lehnertz,Daniela N. Quilliam,M. J. Durham,I. Cardona-Gerena,Linda Bell,Environmental Control,Marina Kuljanin,Suzanne N. Gibbons-Burgener,Ryan P. Westergaard,Lynn E. Sosa,Monica Beddo,Matthew Donahue,Samir Koirala,Courtney M Dewart,Jade Murray-Thompson,L. Peake,Michelle Holshue,Atul Kothari,Jamie Ahlers,Lauren Usagawa,M. Cahill,Erin K Ricketts,Mike Mannell,Farah S Ahmed,Bethany Hodge,Brenton Nesemeier,Katherine Guinther,M. Anand,Jennifer L. White,Joel Ackelsberg,Ellen H. Lee,Devin Charlotte Raman,Carmen Elaine Brown,Nicole Burton,Sara Kate Johnson +115 more
TLDR
Clinicians should test patients with rash consistent with monkeypox,† regardless of whether the rash is disseminated or was preceded by prodrome, and public health efforts should prioritize gay, bisexual, and other men who have sex with men, who are currently disproportionately affected for prevention and testing.Abstract:
Monkeypox, a zoonotic infection caused by an orthopoxvirus, is endemic in parts of Africa. On August 4, 2022, the U.S. Department of Health and Human Services declared the U.S. monkeypox outbreak, which began on May 17, to be a public health emergency (1,2). After detection of the first U.S. monkeypox case), CDC and health departments implemented enhanced monkeypox case detection and reporting. Among 2,891 cases reported in the United States through July 22 by 43 states, Puerto Rico, and the District of Columbia (DC), CDC received case report forms for 1,195 (41%) cases by July 27. Among these, 99% of cases were among men; among men with available information, 94% reported male-to-male sexual or close intimate contact during the 3 weeks before symptom onset. Among the 88% of cases with available data, 41% were among non-Hispanic White (White) persons, 28% among Hispanic or Latino (Hispanic) persons, and 26% among non-Hispanic Black or African American (Black) persons. Forty-two percent of persons with monkeypox with available data did not report the typical prodrome as their first symptom, and 46% reported one or more genital lesions during their illness; 41% had HIV infection. Data suggest that widespread community transmission of monkeypox has disproportionately affected gay, bisexual, and other men who have sex with men and racial and ethnic minority groups. Compared with historical reports of monkeypox in areas with endemic disease, currently reported outbreak-associated cases are less likely to have a prodrome and more likely to have genital involvement. CDC and other federal, state, and local agencies have implemented response efforts to expand testing, treatment, and vaccination. Public health efforts should prioritize gay, bisexual, and other men who have sex with men, who are currently disproportionately affected, for prevention and testing, while addressing equity, minimizing stigma, and maintaining vigilance for transmission in other populations. Clinicians should test patients with rash consistent with monkeypox,† regardless of whether the rash is disseminated or was preceded by prodrome. Likewise, although most cases to date have occurred among gay, bisexual, and other men who have sex with men, any patient with rash consistent with monkeypox should be considered for testing. CDC is continually evaluating new evidence and tailoring response strategies as information on changing case demographics, clinical characteristics, transmission, and vaccine effectiveness become available.§.read more
Citations
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Journal ArticleDOI
Interim Guidance for Prevention and Treatment of Monkeypox in Persons with HIV Infection — United States, August 2022
Jesse O’Shea,Thomas D. Filardo,Sapna Bamrah Morris,John Weiser,Brett W. Petersen,John T. Brooks +5 more
TL;DR: Although data are limited for monkeypox in patients with HIV, prompt diagnosis, treatment, and prevention might reduce the risk for adverse outcomes and limit monkeypox spread.
Journal ArticleDOI
HIV and Sexually Transmitted Infections Among Persons with Monkeypox — Eight U.S. Jurisdictions, May 17–July 22, 2022
Kathryn G. Curran,Kristen Eberly,Olivia Ollinger Russell,Robert E. Snyder,Elisabeth K. Phillips,Eric C Tang,Philip J. Peters,Melissa Sanchez,Ling Hsu,Stephanie E. Cohen,Ekow Kwa Sey,Sherry Yin,Chelsea Foo,William Still,Anil T. Mangla,Brittani Saafir-Callaway,Lauren Barrineau-Vejjajiva,Cristina Meza,E. Burkhardt,Patricia Aikins Murphy,Nora K Kelly,Hillary Spencer,Irina Tabidze,Massimo Pacilli,Carol-Ann E. Swain,Kathleen M. Bogucki,Charlotte DelBarba,Deepa T Rajulu,Andre Dailey,Jessica N. Ricaldi,Leandro Mena,Demetre Daskalakis,Laura H. Bachmann,John T. Brooks,Alexandra M. Oster,Michael Abassian,M. Abrego,David Addo,Bridget J. Anderson,Connie Austin,Kailey Bradley,David Pham Bui,Shua J Chai,Eric G. Chapman,Joseph P. Clement,Catherine Comis,Phoebe Danza,Marisa Anne Pella Donnelly,Kerri Dorsey,Karen Drezner,Alicia Dunajcik,Areesh Fatmee,Amanda Feldpausch,Lauren E Finn,Rebecca Fisher,Kameron Gadawski,Jasmine Gaillard,Varun Gandhi,Amy B. Garlin,Sarah Gillani,Jamilla Green,Megan Hill,Taylor Holly,Virginia Hu,Otto J Ike,Anna Satcher Johnson,Kelly Johnson,Janna L. Kerins,David A. Kern,Bita Khoshhal,Akiko Kimura,Irma Kocer,Colin Korban,Chun-Mai Kuo,Rodriques Lambert,Issa Lee-Hall,Jessica Lorenzo-Luaces,Elise Mara,Amy Marutani,K. M. Miletti,Wilson P. Miranda,Allison Morrow,D. F. Nims,Melissa Ongpin,Chisom Onyeuku,Jessica Pavlick,Eugene Pennisi,Neela Persad,Mary Pomeroy,Kathleen Poortinga,Dylan Atchley Procter,Marisa Ramos,Eli S. Rosenberg,Lori Saathoff-Huber,Nannie Song,Daniel M. Stowell,Deanna L. Sykes,Amanda Terminello,Ebony S Thomas,Christopher Toomey,Brittany Wilbourn,Tanya Williams,Pascale M. Wortley +102 more
TL;DR: It is important that public health officials leverage systems for delivering HIV and STI care and prevention to reduce monkeypox incidence in this population and consideration should be given to prioritizing persons with HIV infection and STIs for vaccination against monkeypox.
Journal ArticleDOI
Severe Monkeypox in Hospitalized Patients — United States, August 10–October 10, 2022
Maureen J Miller,Shama Cash-Goldwasser,Grace E Marx,Caroline Schrodt,Anne Kimball,Kia Padgett,Rebecca S. Noe,David W. McCormick,Joshua M. Wong,Sarah M Labuda,Brian Borah,Isaac Zulu,Amimah Fatima Asif,Gurpreet Kaur,Janet M. McNicholl,Athena P. Kourtis,Andrew Tadros,Sarah Reagan-Steiner,Jana M. Ritter,Yon Yu,Patricia A. Yu,Rachel Clinton,Corrine Parker,Eleanor S. Click,Johanna S. Salzer,Andrea M. McCollum,Brett W. Petersen,Faisal Syed Minhaj,Ericka Brown,Michael P. Fischer,Robert L. Atmar,Andrew R. DiNardo,Ya Yi Xu,Cameron Brown,M. C. Goodman,Ashley Holloman,Julia Gallardo,Hanna Siatecka,G Fatma Huffman,John Powell,Philip Alapat,Pralay K. Sarkar,Nicola A. Hanania,Or Bruck,Steven Brass,Aneesh K. Mehta,Alexandra W. Dretler,Amanda Feldpausch,Jessica Pavlick,Hillary Spencer,Isaac Ghinai,Stephanie R. Black,Laura N. Hernandez-Guarin,Sarah Won,Shivanjali Shankaran,Andrew Simms,Jemma Alarcón,Jesse O’Shea,John T. Brooks,Jennifer H. McQuiston,Margaret A. Honein,Siobhan M. OʼConnor,Kevin Chatham-Stephens,Kevin O'Laughlin,Agam K Rao,Elliot Raizes,Jeremy A W Gold,Sapna Bamrah Morris,Shelby Duessel,Darren Danaie,Angela G Hickman,Ben Griffith,Haddijatou Sanneh,Helena J. Hutchins,Christine Phyathep,Ann Carpenter,Victoria Shelus,Julia Petras,Ian Hennessee,Meryl Davis,Cristin McArdle,Patrick Dawson,Bruce Gutelius,Kristine M. Bisgard,Karen Xue Qi Wong,Romeo R. Galang,Kiran M. Perkins,Thomas D. Filardo,Whitni Davidson,Christina L. Hutson,David Lowe,Jason Zucker,David A. Wheeler,Lu-Xiao He,Aabha Jain,Oleksandr Semeniuk,Devyani Chatterji,Marni B McClure,Lucy X. Li,J.L. Muñoz Mata,Sasha Beselman,Sara L. Cross,Barbara Menzies,Marina Keller,Vishnu Chaturvedi,Andrea Thet,R Carroll,Courtney Hebert,Gopi A. Patel,Vani Gandhi,Alexandra Abrams-Downey,Mehmood Nawab,Emily Landon,Gregory Tse Lee,Emma Kaplan-Lewis,Cyndee Miranda,Anna E. Carmack,Edward C Traver,Susana M. Lazarte,Trish M. Perl,Jeremy Y. Chow,Ellen Kitchell,Ank E. Nijhawan,Onaizah Habib,Allen Bernus,Gabriela Andujar,Kusha Davar,P. J. Holtom,Noah Wald-Dickler,Marco Lorio,J. Gaviria,Vivian S. Chu,Cameron R. Wolfe,Mehri S McKellar,Sumaya Farran,Roque A. Diaz Wong,Tjark Schliep,Raphael Shaw,Pablo Tebas,Aaron Richterman,Michelle B. Aurelius,Leah Peterson,Ronald P. Trible,Tyler Rehman,R Sabzwari,Edward R. Hines,T. Birkey,D. Stokich,Jamie King,Alireza Farabi,Elizabeth R. Jenny-Avital,Lauren Touleyrou,Avnish Sandhu,Gretchen Newman,Divya R. Bhamidipati,Karen J. Vigil,Melissa Caro,Koury Banowski,Tanyanyiwa Chinyadza,Jake Rosenzweig,Michelle Jones,Jose F. Camargo,Ketzela J. Marsh,Eugene W Liu,Richelle Guerrero-Wooley,Paul S. Pottinger +165 more
TL;DR: In the United States, a total of 27,884 monkeypox cases (confirmed and probable) have been reported by the Centers for Disease Control and Prevention (CDC) as of October 21, 2022 as mentioned in this paper .
Journal ArticleDOI
Strategies Adopted by Gay, Bisexual, and Other Men Who Have Sex with Men to Prevent Monkeypox virus Transmission — United States, August 2022
Kevin P. Delaney,Travis Sanchez,Marissa Hannah,O. W. Edwards,Thomas Carpino,Christine Agnew-Brune,Kaytlin J Renfro,Rachel Kachur,Neal Carnes,Elizabeth DiNenno,Amy Lansky,Kathleen A. Ethier,Patrick F. Sullivan,Stefan Baral,Alexandra M. Oster +14 more
Journal ArticleDOI
Monkeypox: epidemiology, pathogenesis, treatment and prevention
Yong Huang,Li Mu,Wei Wang +2 more
TL;DR: In this paper , the authors reviewed the epidemiology of monkeypox, monkeypox virus reservoirs, novel transmission patterns, mutations and mechanisms of viral infection, clinical characteristics, laboratory diagnosis and treatment measures.
References
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Journal ArticleDOI
Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022
TL;DR: The monkeypox virus infection in humans was seldom reported outside African regions where it is endemic as mentioned in this paper , and currently cases are occurring worldwide, but transmission, risk factors, clinical presentation, and outcomes of infection are poorly defined.
Journal ArticleDOI
Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022.
John Thornhill,Sapha Barkati,Sharon Walmsley,Juergen K. Rockstroh,Andrea Antinori,Luke B Harrison,Romain Palich,Achyuta V Nori,I. Reeves,Maximillian S. Habibi,Vanessa Apea,Christoph Boesecke,Linos Vandekerckhove,M. V. Yakubovsky,Elena Sendagorta,José L. Blanco,Eric Florence,Davide Moschese,Fernando Maltez,Abraham Goorhuis,Valérie Pourcher,Pascal Migaud,Sebastian Noe,Claire Pintado,Fabrizio Maggi,Ann-Brit Eg Hansen,Christian Hoffmann,Jezer I Lezama,Cristina Mussini,Anna Maria Cattelan,Keletso Makofane,Darrell H. S. Tan,Silvia Nozza,J. Nemeth,Marina B Klein,Chloe Orkin +35 more
TL;DR: The simultaneous identification of cases outside areas where monkeypox has traditionally been endemic highlights the need for rapid identification and diagnosis of cases to contain further community spread.
Journal ArticleDOI
Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series
Aatish Patel,Julia Bilinska,Jerry Tam,Dayana Da Silva Fontoura,Claire Y Mason,Anna Daunt,Luke B Snell,J. Shaun Murphy,Jack Potter,Cecilia Tuudah,Rohan Sundramoorthi,Movin Abeywickrema,Caitlin Pley,Vasanth V Naidu,G. Nebbia,Emma Aarons,A Botgros,Sam Douthwaite,Claire van Nispen tot Pannerden,Helen Winslow,Aisling Brown,Daniella Chilton,Achyuta V Nori +22 more
TL;DR: These findings confirm the ongoing unprecedented community transmission of monkeypox virus among gay, bisexual, and other men who have sex with men seen in the UK and many other non-endemic countries.
Journal ArticleDOI
Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study
TL;DR: In this article , a multicentre, prospective, observational cohort study was done in three sexual health clinics in Madrid and Barcelona, Spain to investigate clinical and virological characteristics of cases of human monkeypox in Spain.
Journal ArticleDOI
Monkeypox Outbreak — Nine States, May 2022
TL;DR: On May 17, 2022, the Massachusetts Department of Public Health (MDPH) Laboratory Response Network (LRN) laboratory confirmed the presence of orthopoxvirus DNA via real-time polymerase chain reaction (PCR) from lesion swabs obtained from a Massachusetts resident as mentioned in this paper .