Epidemiology of adolescent idiopathic scoliosis
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TLDR
For example, this paper found that the prevalence of curves with higher Cobb angles is substantially higher in girls than in boys, and the female to male ratio rises from 1.5:1 to 3:1 and increases substantially with increasing age.Abstract:
Adolescent idiopathic scoliosis is a common disease with an overall prevalence of 0.47–5.2 % in the current literature. The female to male ratio ranges from 1.5:1 to 3:1 and increases substantially with increasing age. In particular, the prevalence of curves with higher Cobb angles is substantially higher in girls than in boys: The female to male ratio rises from 1.4:1 in curves from 10° to 20° up to 7.2:1 in curves >40°. Curve pattern and prevalence of scoliosis is not only influenced by gender, but also by genetic factors and age of onset. These data obtained from school screening programs have to be interpreted with caution, since methods and cohorts of the different studies are not comparable as age groups of the cohorts and diagnostic criteria differ substantially. We do need data from studies with clear standards of diagnostic criteria and study protocols that are comparable to each other.read more
Citations
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Suv39h1 promotes facet joint chondrocyte proliferation by targeting miR-15a/Bcl2 in idiopathic scoliosis patients.
TL;DR: It is suggested that increased chondrocyte proliferation occurs in the facet joint cartilage of IS patients compared with the control group and may be promoted by the elevated levels of H3K9me3 and SUV39H1, which regulate the miR-15a/Bcl2 pathway.
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Reproducibility of sagittal radiographic parameters in adolescent idiopathic scoliosis—a guide to reference values using serial imaging
Hwee Weng Dennis Hey,Gordon Chengyuan Wong,Chloe Xiaoyun Chan,Leok-Lim Lau,Naresh Kumar,Joseph Shantakumar Thambiah,John Nathaniel Ruiz,Ka-Po Gabriel Liu,Hee-Kit Wong +8 more
TL;DR: Most radiographic sagittal spinal parameters in AIS patients are generally reproducible with some variations up to a maximum of 4°, but natural variation should be taken into account when interpreting these radiography sagittal parameters so as to achieve the most accurate results in surgical planning.
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Accuracy of photogrammetry for detecting adolescent idiopathic scoliosis progression.
Jefferson Soares Leal,Rozilene Maria Cota Aroeira,Vinicius Gressler,Marcelo Greco,Antônio Eustáquio de Melo Pertence,Joel Alves Lamounier +5 more
TL;DR: The photogrammetric method showed good performance for detecting the progression of adolescent idiopathic scoliosis in comparison with the radiographic exam method.
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Sensitivity of MRI parameters within intervertebral discs to the severity of adolescent idiopathic scoliosis.
TL;DR: To measure magnetic resonance imaging parameters including relaxation times, magnetization transfer and diffusion parameters of intervertebral discs in adolescents with idiopathic scoliosis, and to investigate the sensitivity of these MR parameters to the severity of the spine deformities.
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Awake serial body casting for the management of infantile idiopathic scoliosis: is general anesthesia necessary?
Scott M LaValva,Elle M MacAlpine,Noriaki Kawakami,Jigar S. Gandhi,Kazuaki Morishita,Peter Sturm,Sumeet Garg,Michael P. Glotzbecker,Jason B Anari,John M. Flynn,Patrick J. Cahill +10 more
TL;DR: Patients who underwent awake serial casting had similar radiographic outcomes as compared to those who were under general anesthesia during the procedures, suggesting awake casting may provide a safe and effective alternative to the use of general anesthesia in patients with idiopathic infantile scoliosis.
References
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Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
Linheng Li,Ian D. Krantz,Yu Deng,Yu Deng,Anna Genin,Amy B. Banta,Colin Collins,Ming Qi,Barbara J. Trask,Wen Lin Kuo,Joanne Cochran,Teresa Costa,Mary Ella M Pierpont,Elizabeth B. Rand,David A. Piccoli,Leroy Hood,Nancy B. Spinner +16 more
TL;DR: Four distinct coding mutations in JAG1 are demonstrated, providing evidence that it is the causal gene for Alagille syndrome, and supporting the hypothesis that haploinsufficiency for this gene is one of the mechanisms causing the Alagile syndrome phenotype.
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Mutations in the human Jagged1 gene are responsible for Alagille syndrome
Takaya Oda,Abdel G. Elkahloun,Brian L. Pike,Kazuki Okajima,Ian D. Krantz,Anna Genin,David A. Piccoli,Paul S. Meltzer,Nancy B. Spinner,Francis S. Collins,Settara C. Chandrasekharappa +10 more
TL;DR: It is concluded that AGS is caused by haploinsufficiency of JAG1, the human homologue of rat Jagged1, which encodes a ligand for the Notch receptor, an attractive candidate gene for a developmental disorder in humans.
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Adolescent idiopathic scoliosis.
TL;DR: Adolescent idiopathic scoliosis affects 1-3% of children in the at-risk population of those aged 10-16 years and the aetiopathogensis of this disorder remains unknown, with misinformation about its natural history.
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Adult scoliosis: prevalence, SF-36, and nutritional parameters in an elderly volunteer population
Frank J. Schwab,Ashok Dubey,Lorenzo Gamez,Abdelkrim Benchikh El Fegoun,Ki Hwang,Murali Pagala,J.-P. Farcy +6 more
TL;DR: The scoliosis prevalence rate of 68% found in this study reveals a rate significantly higher than reported in other studies, and appears to reflect the targeted selection of an elderly group.
Journal ArticleDOI
Adolescent idiopathic scoliosis.
TL;DR: Adolescent idiopathic scoliosis is a common problem; its prevalence in the general population is about 1.8 percent, if minor curvatures of 5 to 10 degrees are included.
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