Epidemiology of adolescent idiopathic scoliosis
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TLDR
For example, this paper found that the prevalence of curves with higher Cobb angles is substantially higher in girls than in boys, and the female to male ratio rises from 1.5:1 to 3:1 and increases substantially with increasing age.Abstract:
Adolescent idiopathic scoliosis is a common disease with an overall prevalence of 0.47–5.2 % in the current literature. The female to male ratio ranges from 1.5:1 to 3:1 and increases substantially with increasing age. In particular, the prevalence of curves with higher Cobb angles is substantially higher in girls than in boys: The female to male ratio rises from 1.4:1 in curves from 10° to 20° up to 7.2:1 in curves >40°. Curve pattern and prevalence of scoliosis is not only influenced by gender, but also by genetic factors and age of onset. These data obtained from school screening programs have to be interpreted with caution, since methods and cohorts of the different studies are not comparable as age groups of the cohorts and diagnostic criteria differ substantially. We do need data from studies with clear standards of diagnostic criteria and study protocols that are comparable to each other.read more
Citations
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The top 100 classic papers on adolescent idiopathic scoliosis in the past 25 years: a bibliometric analysis of the orthopaedic literature.
Jared M. Newman,Neil V. Shah,Bassel G Diebo,Ariana C Goldstein,Ariana C Goldstein,Marine Coste,Jeffrey J Varghese,Jeffrey J Varghese,Daniel P Murray,Daniel P Murray,Qais Naziri,Qais Naziri,Carl B. Paulino +12 more
TL;DR: Despite recent studies' shorter time frames for impact, citations of AIS research have progressively increased during the past 25 years, and the top 100 cited orthopedic studies were predominantly Level III, retrospective, nonrandomized studies, and therefore, were subject to biases.
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Increasing the motor activity for prevention of spinal deformities in children's of pre-school age
TL;DR: Early diagnostics, regular monitoring, treatment, and the correct motor regimen contribute to the favorable result of disturbed posture in pre-school children.
Genetic Pathway Analysis of Adolescent Idiopathic Scoliosis
TL;DR: The purpose of this project is to investigate the potential that gene participants of a biomolecular pathway are overrepresented within the list of statistically significant genes and that variations to genes in this pathway are the underlying cause of AIS.
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Impact of Pregnancy on Loss of Deformity Correction After Pedicle Screw Instrumentation for Adolescent Idiopathic Scoliosis
Paweł Grabala,Paweł Grabala,Ilkka Helenius,Suken A. Shah,A. Noelle Larson,Jacob M. Buchowski,Michał Latalski,Michał Grabala,Tomasz Guszczyn +8 more
TL;DR: Women who have undergone pedicle screw instrumentation and fusion have had one or more pregnancies do not have curve progression or deterioration in the longer-term outcomes as compared to patients who have not become pregnant.
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Predictive Factors for Outcomes of Overcorrection Nighttime Bracing in Adolescent Idiopathic Scoliosis: A Systematic Review
TL;DR: In this article , a systematic review determined the predictive factors for identifying outcomes of overcorrection nighttime bracing in adolescents with idiopathic scoliosis (AIS) in a systematic search conducted on PubMed, MEDLINE, Scopus, and Embase from January 1986 to January 2021.
References
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Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
Linheng Li,Ian D. Krantz,Yu Deng,Yu Deng,Anna Genin,Amy B. Banta,Colin Collins,Ming Qi,Barbara J. Trask,Wen Lin Kuo,Joanne Cochran,Teresa Costa,Mary Ella M Pierpont,Elizabeth B. Rand,David A. Piccoli,Leroy Hood,Nancy B. Spinner +16 more
TL;DR: Four distinct coding mutations in JAG1 are demonstrated, providing evidence that it is the causal gene for Alagille syndrome, and supporting the hypothesis that haploinsufficiency for this gene is one of the mechanisms causing the Alagile syndrome phenotype.
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Mutations in the human Jagged1 gene are responsible for Alagille syndrome
Takaya Oda,Abdel G. Elkahloun,Brian L. Pike,Kazuki Okajima,Ian D. Krantz,Anna Genin,David A. Piccoli,Paul S. Meltzer,Nancy B. Spinner,Francis S. Collins,Settara C. Chandrasekharappa +10 more
TL;DR: It is concluded that AGS is caused by haploinsufficiency of JAG1, the human homologue of rat Jagged1, which encodes a ligand for the Notch receptor, an attractive candidate gene for a developmental disorder in humans.
Journal ArticleDOI
Adolescent idiopathic scoliosis.
TL;DR: Adolescent idiopathic scoliosis affects 1-3% of children in the at-risk population of those aged 10-16 years and the aetiopathogensis of this disorder remains unknown, with misinformation about its natural history.
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Adult scoliosis: prevalence, SF-36, and nutritional parameters in an elderly volunteer population
Frank J. Schwab,Ashok Dubey,Lorenzo Gamez,Abdelkrim Benchikh El Fegoun,Ki Hwang,Murali Pagala,J.-P. Farcy +6 more
TL;DR: The scoliosis prevalence rate of 68% found in this study reveals a rate significantly higher than reported in other studies, and appears to reflect the targeted selection of an elderly group.
Journal ArticleDOI
Adolescent idiopathic scoliosis.
TL;DR: Adolescent idiopathic scoliosis is a common problem; its prevalence in the general population is about 1.8 percent, if minor curvatures of 5 to 10 degrees are included.
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