Journal ArticleDOI
Epidemiology of Invasive Mycoses in North America
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TLDR
The epidemiologic profiles of these invasive mycoses in North America are discussed, as well as risk factors for infection, and the pathogens’ antifungal susceptibility.Abstract:
The incidence of invasive mycoses is increasing, especially among patients who are immunocompromised or hospitalized with serious underlying diseases. Such infections may be broken into two broad categories: opportunistic and endemic. The most important agents of the opportunistic mycoses are Candida spp., Cryptococcus neoformans, Pneumocystis jirovecii, and Aspergillus spp. (although the list of potential pathogens is ever expanding); while the most commonly encountered endemic mycoses are due to Histoplasma capsulatum, Coccidioides immitis/posadasii, and Blastomyces dermatitidis. This review discusses the epidemiologic profiles of these invasive mycoses in North America, as well as risk factors for infection, and the pathogens' antifungal susceptibility.read more
Citations
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Candida albicans pathogenicity mechanisms
TL;DR: This review presents an update on the current understanding of the pathogenicity mechanisms of this important human pathogen and reveals novel virulence mechanisms have recently been discovered.
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Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment.
TL;DR: Standardized methods for reliable in vitro antifungal susceptibility testing are now available from the Clinical and Laboratory Standards Institute (CLSI) in the United States and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) in Europe.
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Genetic control of Candida albicans biofilm development.
TL;DR: Mechanistic studies have uncovered new mechanisms and signals that govern C. albicans biofilm development and associated drug resistance, thus providing biological insight and therapeutic foresight.
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Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease
TL;DR: The circuitry regulating fungal morphogenesis and drug resistance and the impact of these pathways on virulence are reviewed, which represent a minute fraction of fungal diversity.
References
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Book
Manual of clinical microbiology
TL;DR: A collaborative team of editors and authors from around the world revised the Manual to include the latest applications of genomics and proteomics, producing an authoritative work of two volumes filled with current findings regarding infectious agents, leading-edge diagnostic methods, laboratory practices, and safety guidelines.
Journal ArticleDOI
The Epidemiology of Sepsis in the United States from 1979 through 2000
TL;DR: The rate of sepsis due to fungal organisms increased by 207 percent, with gram-positive bacteria becoming the predominant pathogens after 1987, and the total in-hospital mortality rate fell, yet the total number of deaths continued to increase.
Journal ArticleDOI
Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study
Hilmar Wisplinghoff,Tammy Bischoff,Sandra M. Tallent,Harald Seifert,Richard P. Wenzel,Michael B. Edmond +5 more
TL;DR: The proportion of nosocomial BSIs due to antibiotic-resistant organisms is increasing in US hospitals, and in neutropenic patients, infections with Candida species, enterococci, and viridans group streptococci were significantly more common.
Journal ArticleDOI
Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
TL;DR: Improved non-culture-based diagnostics are needed to expand the potential for preemptive (or early directed) therapy and improve diagnostic, preventive, and therapeutic strategies is necessary to reduce the considerable morbidity and mortality associated with IC.
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