Book ChapterDOI
Epidemiology of Lung Cancer
Ann G. Schwartz,Michele L. Cote +1 more
TLDR
As lung cancer screening becomes more widespread, a validated model will be needed to better define risk groups to inform screening guidelines, however there is not yet a risk prediction model currently recommended for general use.Abstract:
Lung cancer continues to be one of the most common causes of cancer death despite understanding the major cause of the disease: cigarette smoking. Smoking increases lung cancer risk 5- to 10-fold with a clear dose-response relationship. Exposure to environmental tobacco smoke among nonsmokers increases lung cancer risk about 20%. Risks for marijuana and hookah use, and the new e-cigarettes, are yet to be consistently defined and will be important areas for continued research as use of these products increases. Other known environmental risk factors include exposures to radon, asbestos, diesel, and ionizing radiation. Host factors have also been associated with lung cancer risk, including family history of lung cancer, history of chronic obstructive pulmonary disease and infections. Studies to identify genes associated with lung cancer susceptibility have consistently identified chromosomal regions on 15q25, 6p21 and 5p15 associated with lung cancer risk. Risk prediction models for lung cancer typically include age, sex, cigarette smoking intensity and/or duration, medical history, and occupational exposures, however there is not yet a risk prediction model currently recommended for general use. As lung cancer screening becomes more widespread, a validated model will be needed to better define risk groups to inform screening guidelines.read more
Citations
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Journal ArticleDOI
Precision Diagnosis and Treatment for Advanced Non–Small-Cell Lung Cancer
Martin Reck,Klaus F. Rabe +1 more
TL;DR: The authors of this review discuss recent progress in diagnostic and treatment approaches, including molecular characterization to determine the likelihood of a response to targeted agents and immunotherapies.
Journal ArticleDOI
The epidemiology of lung cancer.
TL;DR: In the US, the recent legalization of marijuana for recreational use in many states and the rapid growth of commercially available electronic nicotine delivery systems (ENDS) present challenges to public health for which little short term and no long term safety data is available.
Journal ArticleDOI
Epidemiology of lung cancer
TL;DR: Lung cancer is the leading cause of global cancer incidence and mortality, accounting for an estimated 2 million diagnoses and 1.8 million deaths in men and women, respectively.
Journal ArticleDOI
Second-hand aerosol from tobacco and electronic cigarettes: Evaluation of the smoker emission rates and doses and lung cancer risk of passive smokers and vapers.
Pasquale Avino,Mauro Scungio,Luca Stabile,G. Cortellessa,Giorgio Buonanno,Maurizio Manigrasso +5 more
TL;DR: An experimental campaign was performed to evaluate the exposure to second-hand aerosol from conventional and electronic cigarettes and to estimate the consequent dose received by passive smokers/vapers and the related lung cancer risk.
Journal ArticleDOI
Propofol inhibits lung cancer cell viability and induces cell apoptosis by upregulating microRNA-486 expression.
TL;DR: Propofol might be an ideal anesthetic for lung cancer surgery by effectively inhibiting lung cancer cell viability and inducing cell apoptosis and modulation of miR-486 might contribute to the anti-tumor activity of propofol.
References
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Journal ArticleDOI
Solid Cancer Incidence in Atomic Bomb Survivors: 1958–1998
Dale L. Preston,Elaine Ron,Shoji Tokuoka,Sachiyo Funamoto,Nobuo Nishi,Midori Soda,Kiyohiko Mabuchi,Kazunori Kodama +7 more
TL;DR: There was emerging evidence from the present data that exposure as a child may increase risks of cancer of the body of the uterus, and further evidence that radiation-associated increases in cancer rates persist throughout life regardless of age at exposure.
Summary health statistics for U.S. adults: national health interview survey, 2012.
TL;DR: This report presents detailed tables from the 2012 National Health Interview Survey (NHIS) for the civilian noninstitutionalized adult population, classified by sex, age, race and Hispanic origin, education, current employment status, family income, poverty status, health insurance coverage, marital status, and place and region of residence.