Epidemiology of Sarcoidosis 1946-2013: A Population-Based Study.
Patompong Ungprasert,Eva M. Carmona,James P. Utz,Jay H. Ryu,Cynthia S. Crowson,Eric L. Matteson +5 more
- Vol. 91, Iss: 2, pp 183-188
Reads0
Chats0
TLDR
Sarcoidosis occurred in approximately 10 persons per 100,000 per year, although less than half had respiratory symptoms, and overall mortality was not different from that of the general population.Abstract:
Objective To characterize the epidemiology of sarcoidosis from 1946 through 2013. Patients and Methods An inception cohort of patients with incident sarcoidosis from January 1, 1976, through December 31, 2013, in Olmsted County, Minnesota, was identified based on comprehensive individual medical record review. Inclusion required physician diagnosis supported by histopathologic confirmation, radiologic features of intrathoracic sarcoidosis, and a compatible clinical presentation. Data were collected on demographic characteristics, clinical presentation, laboratory investigations, and mortality. The data were augmented with a previously identified cohort of Olmsted County residents diagnosed as having sarcoidosis in 1946-1975. Incidence rates were age and sex adjusted to the 2010 US white population. Results A total of 448 incident cases of sarcoidosis were identified (mean age, 44.2 years; 52% women). The annual incidence of sarcoidosis was 10.0 per 100,000 population. The incidence of sarcoidosis increased in women from 1950 to 1960, but otherwise there were no significant calendar year trends. However, the peak age at incidence for women shifted from 40 to 59 years in 1950 to 50 to 69 years in 2010. Similarly, the peak age at incidence for men shifted from 30 to 49 years in 1950 to 40 to 59 years in 2010. Ninety-seven percent of patients had intrathoracic involvement, but only 43% had respiratory symptoms. The overall mortality of patients with sarcoidosis was not different from that of the general population (standardized mortality ratio=0.90; 95% CI, 0.74-1.08). Conclusion Sarcoidosis occurred in approximately 10 persons per 100,000 per year. Most of the patients had intrathoracic involvement, although less than half had respiratory symptoms. Overall mortality was not different from that of the general population.read more
Citations
More filters
Journal ArticleDOI
Sarcoidosis in America. Analysis Based on Health Care Use.
Robert P. Baughman,Shelli Field,Ulrich Costabel,Ronald G. Crystal,Daniel A. Culver,Marjolein Drent,Marc A. Judson,Gerhard Wolff +7 more
TL;DR: For patients 18 years of age and older enrolled in a U.S. national administrative database, sarcoidosis was more common among African Americans, but it was reported for all four of the major ethnic groups studied.
Journal ArticleDOI
Joint SNMMI–ASNC Expert Consensus Document on the Role of 18F-FDG PET/CT in Cardiac Sarcoid Detection and Therapy Monitoring
Panithaya Chareonthaitawee,Rob S. Beanlands,Wengen Chen,Sharmila Dorbala,Edward J. Miller,Venkatesh L. Murthy,David H. Birnie,Edward S. Chen,Leslie T. Cooper,Roderick Tung,Eric S. White,Salvador Borges-Neto,Marcelo F. Di Carli,Robert J. Gropler,Terrence D. Ruddy,Thomas H. Schindler,Ron Blankstein,Timothy M. Bateman,Manuel D. Cerqueira,Vasken Dilsizian,Gary V. Heller,David R. Moller,Michael T. Osborne,Mehran M. Sadeghi,Prem Soman +24 more
TL;DR: This research presents a meta-analyses of the determinants of coronary heart disease and stroke in mice and shows clear patterns of disease progression that are consistent with those seen in animals and humans.
Journal ArticleDOI
Joint SNMMI–ASNC expert consensus document on the role of 18F-FDG PET/CT in cardiac sarcoid detection and therapy monitoring
Panithaya Chareonthaitawee,Rob S. Beanlands,Wengen Chen,Sharmila Dorbala,Edward J. Miller,Venkatesh L. Murthy,David H. Birnie,Edward S. Chen,Leslie T. Cooper,Roderick Tung,Eric S. White,Salvador Borges-Neto,Marcelo F. Di Carli,Robert J. Gropler,Terrence D. Ruddy,Thomas H. Schindler,Ron Blankstein +16 more
TL;DR: Joint SNMMI–ASNC expert consensus document on the role of F-FDG PET/CT in cardiac sarcoid detection and therapy monitoring.
Journal ArticleDOI
Epidemiology of sarcoidosis: current findings and future directions:
TL;DR: This review reviews the epidemiological tools used, the incidence and prevalence of disease, mortality and cancer risk after sarcoidosis and nongenetic risk factors for sarcoids, and concludes that leveraging existing epidemiological data to conduct etiological studies aimed towards understanding and preventing disease is critical for future sar coidosis research.
References
More filters
Journal Article
ATS/ERS/WASOG statement on sarcoidosis. American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and other Granulomatous Disorders.
Gary W. Hunninghake,Ulrich Costabel,Masayuki Ando,Robert P. Baughman,Jean-François Cordier,du Bois R,A. Eklund,M Kitaichi,Lynch J,Rizzato G,Cecile S. Rose,Olof Selroos,Gianpietro Semenzato,Om P. Sharma +13 more
Journal ArticleDOI
Racial Differences in Sarcoidosis Incidence: A 5-Year Study in a Health Maintenance Organization
TL;DR: The results should be more generalizable than previous studies done with select populations and should serve as a useful frame of reference for future epidemiologic research of sarcoidosis.
Journal ArticleDOI
History of the Rochester Epidemiology Project: Half a Century of Medical Records Linkage in a US Population
Walter A. Rocca,Barbara P. Yawn,Barbara P. Yawn,Jennifer L. St. Sauver,Brandon R. Grossardt,L. Joseph Melton +5 more
TL;DR: The Rochester Epidemiology Project can serve as a model for the development of similar research infrastructures in the United States and worldwide and compare the REP with other medical information systems.
Related Papers (5)
Clinical Characteristics of Patients in a Case Control Study of Sarcoidosis
Robert P. Baughman,Alvin S. Teirstein,Marc A. Judson,Milton D. Rossman,Henry Yeager,Eddy A. Bresnitz,Louis DePalo,Gary M. Hunninghake,Michael C. Iannuzzi,Carol J. Johns,Geoffrey McLennan,David R. Moller,Lee S. Newman,David L. Rabin,Cecile S. Rose,Benjamin A. Rybicki,Steven E. Weinberger,Michael L. Terrin,Genell L. Knatterud,Reuben Cherniak +19 more
A Case Control Etiologic Study of Sarcoidosis: Environmental and Occupational Risk Factors
Lee S. Newman,Cecile S. Rose,Eddy A. Bresnitz,Milton D. Rossman,Juliana Barnard,Margaret Frederick,Michael L. Terrin,Steven E. Weinberger,David R. Moller,Geoffrey McLennan,Gary M. Hunninghake,Louis DePalo,Robert P. Baughman,Michael C. Iannuzzi,Marc A. Judson,Genell L. Knatterud,Bruce Thompson,Alvin S. Teirstein,Henry Yeager,Carol J. Johns,David L. Rabin,Benjamin A. Rybicki,Reuben M. Cherniack +22 more
Ats/ers/wasog statement on sarcoidosis. sarcoidosis statement committee. american thoracic society. european respiratory society. world association for sarcoidosis and other granulomatous disorders
U Costabel,G W Hunninghake +1 more