Journal ArticleDOI
Epithelium modulates the reactivity of ovalbumin-sensitized guinea-pig airway smooth muscle.
TLDR
The epithelium appears not only to modulate the reactivity of the tissues to bronchoactive agents, but it also influences the magnitude of the contractile response following antigen challenge.About:
This article is published in Life Sciences.The article was published on 1986-06-30. It has received 49 citations till now. The article focuses on the topics: Respiratory epithelium & Ovalbumin.read more
Citations
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Book ChapterDOI
The pathobiology of bronchial asthma.
Jonathan P. Arm,Tak H. Lee +1 more
TL;DR: The severity of clinical asthma correlates with several measurements of the severity of the inflammatory response, suggesting a crucial role for airway inflammation in the pathophysiology of the disease.
Journal ArticleDOI
Characterization of neurokinin effects and receptor selectivity in human isolated bronchi.
Emmanuel Naline,Philippe Devillier,Guy Drapeau,Lucien Toty,Hayssam Bakdach,Domenico Regoli,Charles Advenier +6 more
TL;DR: Removal of the epithelium significantly enhanced the contractile responses to the three neurokinins and also to theNK-2 selective agonist, suggesting the presence of NK-2 receptors in human bronchi.
Journal ArticleDOI
Comparison of the effects of epithelium removal and of an enkephalinase inhibitor on the neurokinin-induced contractions of guinea-pig isolated trachea.
TL;DR: It was suggested that the supersensitivity to neurokinins produced by epithelium removal was due neither to the elimination of a permeability barrier nor to reduced production of a relaxant factor, but mainly to reduced peptide degradation.
Journal ArticleDOI
The effects of epithelium removal on the sensitivity of guinea-pig isolated trachealis to bronchodilator drugs.
TL;DR: The results suggest that in the guinea‐pig, the tracheal epithelium is a major source of extraneuronal uptake for catecholamines, and that the increase in trachealis sensitivity to isoprenaline following epit Helium removal is probably due to loss of these sites ofextraneuronic uptake.
Journal ArticleDOI
Epithelium-derived relaxing factor(s) and bronchial reactivity.
TL;DR: Observations suggest that the bronchial epithelium releases an inhibitory factor that partially counteracts activation of the airway smooth muscle by bronchoconstrictor substances.
References
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Journal ArticleDOI
Respiratory epithelium inhibits bronchial smooth muscle tone
TL;DR: The results suggest that respiratory epithelial cells may generate an inhibitory signal to decrease the responsiveness of bronchial smooth muscle to contractile agonists and augment the effectiveness of inhibitory stimuli.
Journal Article
In Vitro Studies of Antigen-Induced Bronchospasm: Effect of Antihistamine and SRS-A Antagonist on Response of Sensitized Guinea Pig and Human Airways to Antigen
TL;DR: It is suggested that both histamine and SRS-A are involved in the response of sensitized guinea pig and human airway tissue to antigen, with histamine mediating the early phase of the contraction and S RS-A primarily mediates the protracted phase.
Journal ArticleDOI
Immunologically induced alterations of airway smooth muscle cell membrane
M Souhrada,J. F. Souhrada +1 more
TL;DR: The heat-sensitive serum factor, presumably reaginic antibodies, appears to be responsible for the membrane hyperpolarization of airway smooth muscle cells after sensitization.
Journal ArticleDOI
The Role of Mast Cells in Asthma
TL;DR: Evidence implicating mast cells in the induction of airway muscle constriction and mucosal inflammation includes direct studies of mast cell secretion, measurement of histamine release, and inhibition of asthmatic reactions with antihistamines and with the inhibitor ofmast cell degranulation, sodium cromoglycate.