Journal ArticleDOI
Errors in development of fetuses and placentas from in vitro-produced bovine embryos.
TLDR
The term 'abnormal offspring syndrome (AOS)' is introduced and a classification system of developmental outcomes is proposed to facilitate research efforts on the mechanisms of the various abnormal phenotypes.About:
This article is published in Theriogenology.The article was published on 2006-01-07. It has received 383 citations till now. The article focuses on the topics: Offspring & Placentation.read more
Citations
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Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning.
Xiangzhong Yang,Sadie L. Smith,X. Cindy Tian,Harris A. Lewin,Jean-Paul Renard,Teruhiko Wakayama +5 more
TL;DR: The recent literature on nuclear reprogramming by SCNT is reviewed, including studies of gene expression, DNA methylation, chromatin remodeling, genomic imprinting and X chromosome inactivation, which seems to be highly efficient.
Journal ArticleDOI
Pivotal periods for pregnancy loss during the first trimester of gestation in lactating dairy cows.
Milo C. Wiltbank,Giovanni M. Baez,A. Garcia-Guerra,Mateus Z. Toledo,Pedro L.J. Monteiro,L. F. Melo,L. F. Melo,Julian C Ochoa,José E. P. Santos,Roberto Sartori,Roberto Sartori +10 more
TL;DR: There are varied causes for pregnancy losses during each pivotal period that correspond to key physiological changes in the embryo, uterine environment, and ovary and strategies to reduce these losses are likely to require a multifaceted approach using rational methods that target the critical physiology in each pivotalperiod.
Journal ArticleDOI
Effect of culture environment on gene expression and developmental characteristics in IVF-derived embryos
TL;DR: Current literature is reviewed, with emphasis on the bovine model, demonstrating evidence for an effect of post fertilization culture environment on embryo gene expression and quality.
Journal ArticleDOI
Epigenetic reprogramming in embryonic and foetal development upon somatic cell nuclear transfer cloning
TL;DR: The following article reviews the present knowledge on the epigenetic reprogramming of the transferred somatic cell nucleus, with emphasis on DNA methylation, imprinting, X-chromosome inactivation and telomere length restoration in bovine development.
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Components of oviduct physiology in eutherian mammals.
TL;DR: Classical oviduct physiology is summarised, and the potential molecular consequences of temperature gradients within the duct lumen examined.
References
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Journal ArticleDOI
DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI
Epigenetic Reprogramming in Mammalian Development
Wolf Reik,Wendy Dean,Jörn Walter +2 more
TL;DR: What is known about reprogramming in mammals and how it might relate to developmental potency and imprinting are discussed, including whether or not methylation is involved in the control of gene expression during normal development.
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Chromatin modification and epigenetic reprogramming in mammalian development
TL;DR: The regulation of higher-order chromatin structures by DNA methylation and histone modification is crucial for genome reprogramming during early embryogenesis and gametogenesis, and for tissue-specific gene expression and global gene silencing.
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Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos.
Wendy Dean,Fátima Santos,Miodrag Stojkovic,Valeri Zakhartchenko,Jörn Walter,Eckhard Wolf,Wolf Reik +6 more
TL;DR: Mouse embryos undergo genome-wide methylation reprogramming by demethylation in early preimplantation development, followed by remethylation thereafter, and it is shown that epigenetic reprograming occurs aberrantly in most cloned embryos.
Journal ArticleDOI
Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture
Lorraine E. Young,Kenneth Fernandes,T.G. McEvoy,Simon C. Butterwith,Carlos G. Gutiérrez,Catherine Carolan,P.J. Broadbent,John J. Robinson,Ian Wilmut,Kevin D. Sinclair +9 more
TL;DR: The demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes, and highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.