Estimation of average heterozygosity and genetic distance from a small number of individuals
TLDR
It is shown that the number of individuals to be used for estimating average heterozygosity can be very small if a large number of loci are studied and the average heter homozygosity is low.Abstract:
The magnitudes of the systematic biases involved in sample heterozygosity and sample genetic distances are evaluated, and formulae for obtaining unbiased estimates of average heterozygosity and genetic distance are developed. It is also shown that the number of individuals to be used for estimating average heterozygosity can be very small if a large number of loci are studied and the average heterozygosity is low. The number of individuals to be used for estimating genetic distance can also be very small if the genetic distance is large and the average heterozygosity of the two species compared is low.read more
Citations
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spagedi: a versatile computer program to analyse spatial genetic structure at the individual or population levels
Olivier J. Hardy,Xavier Vekemans +1 more
TL;DR: Spag e d i as discussed by the authors is a software primarily designed to characterize the spatial genetic structure of mapped individuals or populations using genotype data of codominant markers, which is useful for detecting isolation by distance within or among populations and estimating gene dispersal parameters; assessing genetic relatedness between individuals and its actual variance, a parameter of interest for marker-based inferences of quantitative inheritance.
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Evolutionary relationship of dna sequences in finite populations
TL;DR: These studies indicate that the estimates of the average number of nucleotide differences and nucleon diversity have a large variance, and a large part of this variance is due to stochastic factors.
Journal ArticleDOI
Microsatellite Null Alleles and Estimation of Population Differentiation
TL;DR: F(ST) estimation from corrected genotype frequencies performed well when restricted to visible allele sizes, and the use of the genetic distance of Cavalli-Sforza and Edwards (1967) corrected by the conventional method gave better estimates than those obtained without correction.
Journal ArticleDOI
Accuracy of estimated phylogenetic trees from molecular data. II. Gene frequency data.
TL;DR: In this article, the accuracies and efficiencies of three different methods of making phylogenetic trees from gene frequency data were examined by using computer simulation, and the results obtained indicate that in all tree-making methods examined, accuracies of both the topology and branch lengths of a reconstructed tree (rooted tree) are very low when the number of loci used is less than 20 but gradually increase with increasing number of nodes.
Journal ArticleDOI
Analysis of population genetic structure with RAPD markers
Michael Lynch,Brook G. Milligan +1 more
TL;DR: Estimators for several population‐genetic parameters (gene and genotype frequencies, within‐ and between‐population heterozygosities, degree of inbreeding and population subdivision, and degree of individual relatedness) are presented along with expressions for their sampling variances.
References
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Testing the neutral mutation hypothesis by distribution of single locus heterozygosity.
TL;DR: One of the most controversial issues in population genetics at present is whether the widespread protein variation in natural populations is maintained by some form of balancing selection or merely represents the drifting polymorphism of neutral or nearly neutral mutations.
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