Open AccessJournal Article
Estrogen receptors in 7,12-dimethylbenz (a) anthracene (DMBA) induced pancreatic carcinoma in rats and in human pancreatic carcinoma.
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This article is published in Clinical Oncology.The article was published on 1982-03-01 and is currently open access. It has received 28 citations till now. The article focuses on the topics: DMBA & 7,12-Dimethylbenz[a]anthracene.read more
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The pharmacology and clinical uses of tamoxifen
B. J.A. Furr,Virgil Craig Jordan +1 more
Journal ArticleDOI
Biology of pancreatic cancer.
TL;DR: This review sets out to explore the mechanism which may be involved in malignant change of the exocrine pancreas and from an understanding of this new biology, new treatment strategies may be possible for patients with pancreatic cancer.
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A prospective randomised controlled trial of tamoxifen and cyproterone acetate in pancreatic carcinoma.
J. J. Keating,Philip J. Johnson,A. M. G. Cochrane,B. G. Gazzard,N Krasner,P. M. Smith,P. N. Trewby,P. G. Wheeler,S. P. Wilkinson,Roger Williams +9 more
TL;DR: Cox regression analysis of 12 clinical and biochemical features showed that, for the entire group of patients, survival was significantly longer in younger patients, those undergoing surgical bypass and those with better initial performance status, but the difference in survival still did not achieve statistical significance.
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Tamoxifen therapy in unresectable adenocarcinoma of the pancreas and the papilla of Vater.
TL;DR: There were no statistically significant differences between the two groups according to age, Karnofsky performance index, tumour node metastasis (TNM) stage, operative treatment or other patient characteristics, and additional retrospective analyses of sex and stage revealed no beneficial effect of tamoxifen upon survival.
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Pancreatic cancer: a review of emerging therapies.
TL;DR: This paper reviews emerging therapies for pancreatic carcinoma, including the use of somatostatin analogues and antiandrogens as adjuvant therapy; inhibition of tumour growth and metastasis by inhibitors of matrix metalloproteinases and angiogenesis, and by small molecules such as retinoids.