Etiology of posterior subcapsular cataracts based on a review of risk factors including aging, diabetes, and ionizing radiation.
Richard B. Richardson,Richard B. Richardson,Elizabeth A. Ainsbury,Christina Rapp Prescott,Frank J. Lovicu +4 more
TLDR
It is hypothesized that the development of PSC opacities is a two-stage process, which accounts for risk factors, such as aging, diabetes and ionizing radiation, which directly affects LECs and the lens.Abstract:
Since the exact development of posterior subcapsular cataracts (PSCs) is poorly understood, we review various risk factors and propose a two-stage etiology for PSCs. The biological mechanisms assoc...read more
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Journal Article
Cataract Formation Following Vitreoretinal procedures
Ron A. Adelman,Hao Feng +1 more
TL;DR: In this paper, the incidence and prevalence of cataract formation, progression, and extraction in patients that underwent vitreoretinal procedures and to evaluate factors that can potentially predispose patients to postoperative cataracts.
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Immune responses to injury and their links to eye disease.
Mary Ann Stepp,A. Sue Menko +1 more
TL;DR: In this paper, the role of inflammation and fibrosis in the progression of age-related pathologies of the cornea and the lens as well as in glaucoma, the formation of epiretinal membranes, and in proliferative vitreoretinopathy.
Journal ArticleDOI
Antioxidant Defenses in the Human Eye: A Focus on Metallothioneins.
Ana Álvarez-Barrios,Lydia Álvarez,Montserrat García,Enol Artime,Rosario Pereiro,Héctor González-Iglesias +5 more
TL;DR: The state of the art of metallothioneins, including the isoforms classification, the main functions described to date, the Zn-MT redox cycle as antioxidant defense system, and the antioxidant activity of ZnMTs in the ocular surface, lens, retina and its retinal pigment epithelium, dependent on the number of occupied zinc-binding sites, are comprehensively reviewed in this article.
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Hallmarks of lens aging and cataractogenesis.
TL;DR: In this paper, the authors provide an overview of the sources and essential functions of lens ROS, antioxidative defenses, and changes in the major regulatory systems that serve to maintain the finely tuned balance of oxidative signaling vs. oxidative stress in lens cells.
Journal ArticleDOI
Immune cells in lens injury repair and fibrosis.
Janice L. Walker,A. Sue Menko +1 more
TL;DR: In this paper, it was shown that resident and recruited immune cells are essential elements of lens homeostasis and repair, but they also become the agents of disease, particularly as progenitors of pro-fibrogenic myofibroblasts.
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